Multiple Sclerosis

1. Front Matter

   Pages i-xv

   PDF

2. Signs and Symptoms of Multiple Sclerosis

   • Stanley van den Noort

   Pages 1-14

3. Differential Diagnosis, Clinical Features, and Prognosis of Multiple Sclerosis

   • Michael J. Olek

   Pages 15-53

4. Role of Magnetic Resonance Imaging in the Diagnosis and Prognosis of Multiple Sclerosis

   • Robert Zivadinov, Rohit Bakshi

   Pages 55-89

5. Cognitive Dysfunction in Multiple Sclerosis

   • Darcy Cox, Laura Julian

   Pages 91-102

6. Multiple Sclerosis, Genetics, and Autoimmunity

   • Michael Demetriou

   Pages 103-112

7. B-Cell Immunity in Multiple Sclerosis

   • Yufen Qin, Pierre Duquette

   Pages 113-130

8. Multiple Sclerosis

   • Alex C. Tselis, Omar A. Khan

   Pages 131-143

9. Pregnancy and Multiple Sclerosis

   • Christina Caon

   Pages 145-159

10. Treatment of Progressive Multiple Sclerosis

    • Norman Wang

    Pages 161-170

11. Cyclophosphamide Therapy for Multiple Sclerosis

    • Derek R. Smith

    Pages 171-191

12. Repair and Neuroprotective Strategies in Multiple Sclerosis

    • Fernando Dangond

    Pages 193-207

13. Future Therapies for Multiple Sclerosis

    • Michael J. Olek

    Pages 209-234

14. Back Matter

    Pages 235-245

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A synthesis of current concepts about the evaluation, treatment, and future directions in MS. On the evaluation side, the authors review the use of MRI, magnetic resonance spectroscopy, functional MRI, and three-dimensional MRI, and consider the rapidly developing body of pathologic information they have yielded. On the treatment side, the focus is on recently approved medications (Novantrone), new indications for medications (CHAMPS Trial), medications in development (Oral Interferon Tau, Oral Copaxone, and Oral Cellcept), immunosuppressive therapy for both progressive disease and symptomatic therapy; the current medications for treating relapsing-remitting MS (Avonex, Betaseron, and Copaxone) are also discussed. For future directions, the authors present the current best thinking, as well as the latest discoveries in immunology relating to MS, including groundbreaking B-cell research and its applications to specific immunotherapies, and the use of immune markers for tracking the disease.

• autoimmunity
• genetics
• immunotherapy
• interferon
• magnetic resonance imaging (MRI)

From the reviews:

"...offers a practical, management-oriented approach to MS and interpretation of current clinical literature. Unique to this publication is the review of pregnancy and cognitive issues." - Doody's Health Sciences Book Review Journal

"To provide current concepts, approaches to management, and future directions in multiple sclerosis research. …This multiauthored text contains chapters covering clinical features, investigations, underlying mechanisms, and approaches to treatment of multiple sclerosis, with an attempt to outline future directions. … The views and discussions in the book are fresh and up-to-date. … Olek, summarizes the differential diagnosis, clinical features, and prognosis of multiple sclerosis and is the strongest and most important … for general physicians." (Jock T. Murray, Annals of Internal Medicine, Vol. 142 (9), 2005)

"This multiauthor book consists of a series of 12 monographs on the various clinical aspects of multiple sclerosis and, as such, is aimed primarily at the general physician … . it is a well-written text and neuroradiologists with a specific interest in multiple sclerosis will find the wealth of discussion on the current and future treatment strategies of the disease useful. … This text might be more useful to junior medical staff starting research projects in the area of multiple sclerosis … ." (Amlyn L. Evans and Daniel J. A. Connolly, Neuroradiology, Vol. 46, 2006)

• Multiple Sclerosis Center, Department of Neurology, University of California, Irvine

  Michael J. Olek

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