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Protein Misfolding, Aggregation and Conformational Diseases

Part A: Protein Aggregation and Conformational Diseases

  • Book
  • © 2006

Overview

Editors:
  1. Vladimir N. Uversky

    1. Department of Biochemistry and Molecular Biology Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis
      Institute for Biological Instrumentation, Russian Academy of Sciences Pushchino, Moscow Region, Russia

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    You can also search for this editor in PubMed   Google Scholar

  2. Anthony L. Fink

    1. Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Fills the gap of what has not been discussed in protein review and protocol books
  • Includes supplementary material: sn.pub/extras

Part of the book series: Protein Reviews (PRON, volume 4)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Structural and Conformational Prerequisites of Amyloidogenesis

    1. Structural and Conformational Prerequisites of Amyloidogenesis

      • Vladimir N. Uversky, Ariel Fernández, Anthony L. Fink
      Pages 1-20

  3. The Generic Nature of Protein Folding and Misfolding

    1. The Generic Nature of Protein Folding and Misfolding

      • Christopher M. Dobson
      Pages 21-41

  4. Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation

    1. Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation

      • Fabrizio Chiti
      Pages 43-59

  5. Cytotoxic Intermediates in the Fibrillation Pathway: Aβ Oligomers in Alzheimer’s Disease as a Case Study

    1. Cytotoxic Intermediates in the Fibrillation Pathway: Aβ Oligomers in Alzheimer’s Disease as a Case Study

      • William L. Klein
      Pages 60-81

  6. Glycosaminoglycans, Proteoglycans, and Conformational Disorders

    1. Glycosaminoglycans, Proteoglycans, and Conformational Disorders

      • Gregory J. Cole, I.-Hsuan Liu
      Pages 83-100

  7. Apolipoproteins in Different Amyloidoses

    1. Apolipoproteins in Different Amyloidoses

      • Marcin Sadowski, Thomas Wisniewski
      Pages 101-122

  8. Oxidative Stress and Protein Deposition Diseases

    1. Oxidative Stress and Protein Deposition Diseases

      • Joseph R. Mazzulli, Roberto Hodara, Summer Lind, Harry Ischiropoulos
      Pages 123-133

  9. Chaperone and Conformational Disorders

    1. Front Matter

      Pages 135-135
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    2. Chaperone Suppression of Aggregated Protein Toxicity

      • Jennifer L. Wacker, Paul J. Muchowski
      Pages 137-164

    3. Mechanisms of Active Solubilization of Stable Protein Aggregates by Molecular Chaperones

      • Pierre Goloubinoff, Anat Peres Ben-Zvi
      Pages 165-174

  10. The Aggresome: Proteasomes, Inclusion Bodies, and Protein Aggregation

    1. The Aggresome: Proteasomes, Inclusion Bodies, and Protein Aggregation

      • Jennifer A. Johnston
      Pages 175-222

  11. Protein Aggregation, Ion Channel Formation, and Membrane Damage

    1. Protein Aggregation, Ion Channel Formation, and Membrane Damage

      • Bruce L. Kagan
      Pages 223-236

  12. Visualization of Protein Deposits In Vivo

    1. Front Matter

      Pages 237-237
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  14. Visualization of Protein Deposits In Vivo

    1. Immunohistological Study of Experimental Murine AA Amyloidosis

      • Mie Kuroiwa, Kimiko Aoki, Naotaka Izumiyama
      Pages 277-283

  15. Visualization of Protein Deposits In Vitro

    1. Front Matter

      Pages 285-285
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  16. Visualization of Protein Deposits In Vitro

    1. Reporters of Amyloid Structure

      • Harry LeVine III
      Pages 287-302

    2. Three-Dimensional Structural Analysis of Amyloid Fibrils by Electron Microscopy

      • Sara Cohen-Krausz, Helen R. Saibil
      Pages 303-313

    3. Atomic Force Microscopy

      • Justin Legleiter, Tomasz Kowalewski
      Pages 315-334
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Keywords

About this book

This volume fills the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. It is devoted to the general questions of conformational disorders and includes discussion of involvement of such common factors as molecular chaperones, oxidative damage, proteasome, glycosoaminoglycans, serum amyloid protein P and several others in the development of different disorders. Some experimental techniques applicable for the visualization of protein deposition in vivo and in vitro are also present.

Editors and Affiliations

  • Department of Biochemistry and Molecular Biology Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis

    Vladimir N. Uversky

  • Institute for Biological Instrumentation, Russian Academy of Sciences Pushchino, Moscow Region, Russia

    Vladimir N. Uversky

  • Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

    Anthony L. Fink

Bibliographic Information

  • Book Title: Protein Misfolding, Aggregation and Conformational Diseases

  • Book Subtitle: Part A: Protein Aggregation and Conformational Diseases

  • Editors: Vladimir N. Uversky, Anthony L. Fink

  • Series Title: Protein Reviews

  • DOI: https://doi.org/10.1007/b136464

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2006

  • Hardcover ISBN: 978-0-387-25918-5Published: 13 June 2006

  • Softcover ISBN: 978-1-4419-3851-0Published: 29 November 2010

  • eBook ISBN: 978-0-387-25919-2Published: 24 November 2007

  • Edition Number: 1

  • Number of Pages: XVIII, 419

  • Topics: Life Sciences, general, Immunology, Cell Biology

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