Statistics Applied to Clinical Trials

1. Front Matter

   Pages I-XV

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2. Introduction to the Statistical Analysis of Clinical Trials, Continuous Data Analysis

   • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

   Pages 1-24

3. Equivalence Testing

   • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

   Pages 25-35

4. Power, Sample Size

   • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

   Pages 37-56

5. Proportional Data Analysis: Part-1

   • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

   Pages 57-71

6. Proportional Data Analysis: Part 2

   • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

   Pages 73-102

7. Meta-Analysis

   • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

   Pages 103-122

8. Interim Analysis

   • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

   Pages 123-132

9. Multiple Testing

   • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

   Pages 133-145

10. Principles of Linear Regression Analysis

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

    Pages 147-157

11. Subgroup Analysis Using Regression Modeling

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

    Pages 159-173

12. Relationship Among Statistical Distributions

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

    Pages 175-188

13. Statistics is Not Bloodless Algebra

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

    Pages 189-195

14. Bias Due to Conflicts of Interests, Some Guidelines

    • Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

    Pages 197-202

15. Back Matter

    Pages 203-226

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The authors have taught statistics and given statistics workshops in France and the Netherlands for almost 4 years by now. Their material, mainly on power point, consists of 12 lectures that have been continuously changed and improved by interaction with various audiences. For the purpose of the current book simple English text has been added to the formulas and figures, and the power points sheets have been rewritten in the format given by Kluwer Academic Publishers. Cartoons have been removed, since this is not so relevant for the transmission of thought through a written text, and at the end of each lecture (chapter) a representative number of questions and exercises for self-assessment have been added. At the end of the book detailed answers to the questions and exercises per lecture are given. The book has been produced with the same size and frontpage as the textbook "Statistics Applied To Clinical Trials" by the same authors and edited by same publishers ( 2nd Edition, DordrechtiBostonlLondon, 2002), and can be applied together with the current self-assessment book or separately. The current self-assessment book is different from the texbook, because it focuses on the most important aspects rather than trying to be complete. So, it does not deal with all of the subjects assessed in the texbook. Instead, it repeats on and on the principle things that are needed for every analysis, and it gives many examples that are further explained by arrows in the figures.

• clinical trial
• data analysis
• linear regression
• research
• statistics

• European Interuniversity College of Pharmaceutical Medicine Lyon, France

  Ton J. Cleophas, Aeilko H. Zwinderman

• Department Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands

  Ton J. Cleophas

• Department Biostatistics and Epidemiology, Academic Medical Center Amsterdam, Netherlands

  Aeilko H. Zwinderman

• Technical University, Delft, Netherlands

  Toine F. Cleophas

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