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Immunity, Tumors and Aging: The Role of HSP70

  • Book
  • © 2013

Overview

Authors:
  1. Igor Malyshev

    1. Medicine and Dentistry, Department of Pathophysiology, Moscow State University of, Moscow, Russia

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Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology (BRIEFSBIOCHEM)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xi
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  2. A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle

    • Igor Malyshev
    Pages 1-13

  3. The Functions of HSP70 in Normal Cells

    • Igor Malyshev
    Pages 15-29

  4. HSP70 in Damaged Cells

    • Igor Malyshev
    Pages 31-45

  5. Mechanisms of Activation and Inactivation of HSP70 Synthesis

    • Igor Malyshev
    Pages 47-61

  6. HSP70 in the Immune Responses

    • Igor Malyshev
    Pages 63-82

  7. HSP70 in Carcinogenesis

    • Igor Malyshev
    Pages 83-98

  8. HSP70 in Aging

    • Igor Malyshev
    Pages 99-111

  9. The Role of HSP70 in the Protection of: (A) The Brain in Alzheimer’s Disease and (B) The Heart in Cardiac Surgery

    • Igor Malyshev
    Pages 113-139

  10. Back Matter

    Pages 141-141
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Keywords

About this book

The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiac surgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.

Authors and Affiliations

  • Medicine and Dentistry, Department of Pathophysiology, Moscow State University of, Moscow, Russia

    Igor Malyshev

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