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The Future of Aging

Pathways to Human Life Extension

  • Book
  • © 2010

Overview

Editors:
  1. Gregory M. Fahy

    1. Intervene Biomedical, LLC, Norco, USA

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  2. Michael D. West

    1. BioTime, Inc., Alameda, USA

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  3. L. Stephen Coles

    1. Institute of Molecular Biology Department of Chemistry and Biochemistry Young Hall, University of California, Los Angeles, USA

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    You can also search for this editor in PubMed   Google Scholar

  4. Steven B. Harris

    1. Critical Care Research, Inc., Rancho Cucamonga, USA

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  • Showcases 17 interventions with the potential to make a material difference
  • The showcased interventions include many that the reader is likely to be unaware of
  • Contains much unique information that can be found no where else
  • Contains unique perspectives that can be found no where else
  • Intended to introduce and make the reader think about new ideas

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xvii
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  3. The Future of Aging

    1. Front Matter

      Pages 225-225
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    2. An Approach to Extending Human Lifespan Today

      • Christopher B. Heward
      Pages 227-278

    3. Near Term Prospects for Ameliorating Cardiovascular Aging

      • Roger Yu, Kaveh Navab, Mohamad Navab
      Pages 279-306

    4. Near Term Prospects for Broad Spectrum Amelioration of Cancer

      • Zheng Cui
      Pages 307-329

    5. Small Molecule Modulators of Sirtuin Activity

      • Francisco J. Alcaín, Robin K. Minor, José M. Villalba, Rafael de Cabo
      Pages 331-356

    6. Evolutionary Nutrigenomics

      • Michael R. Rose, Anthony D. Long, Laurence D. Mueller, Cristina L. Rizza, Kennedy C. Matsagas, Lee F. Greer et al.
      Pages 357-366

    7. Biological Effects of Calorie Restriction: Implications for Modification of Human Aging

      • Stephen R. Spindler
      Pages 367-438

    8. Calibrating Notch/TGF-β Signaling for Youthful, Healthy Tissue Maintenance and Repair

      • Morgan Carlson, Irina M. Conboy
      Pages 439-449

    9. Embryonic Stem Cells: Prospects of Regenerative Medicine for the Treatment of Human Aging

      • Michael D. West
      Pages 451-487

    10. Maintenance and Restoration of Immune System Function

      • Richard Aspinall, Wayne A. Mitchell
      Pages 489-520

    11. Mitochondrial Manipulation as a Treatment for Aging

      • Rafal Smigrodzki, Francisco R. Portell
      Pages 521-541

    12. Life Extension by Tissue and Organ Replacement

      • Anthony Atala
      Pages 543-571
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Keywords

About this book

Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context. Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete. Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology. The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.

Editors and Affiliations

  • Intervene Biomedical, LLC, Norco, USA

    Gregory M. Fahy

  • BioTime, Inc., Alameda, USA

    Michael D. West

  • Institute of Molecular Biology Department of Chemistry and Biochemistry Young Hall, University of California, Los Angeles, USA

    L. Stephen Coles

  • Critical Care Research, Inc., Rancho Cucamonga, USA

    Steven B. Harris

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