Homocysteine in Protein Structure/Function and Human Disease

1. Front Matter

   Pages i-xiii

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2. Introduction

   • Hieronim Jakubowski

   Pages 1-5

3. An Overview of Homocysteine Metabolism

   • Hieronim Jakubowski

   Pages 7-18

4. Homocysteine-Thiolactone

   • Hieronim Jakubowski

   Pages 19-53

5. Discoveries of Protein S- and N-Homocysteinylation

   • Hieronim Jakubowski

   Pages 55-57

6. N-Homocysteinyl-Proteins

   • Hieronim Jakubowski

   Pages 59-105

7. Pathophysiological Consequences of Protein N-Homocysteinylation

   • Hieronim Jakubowski

   Pages 107-119

8. S-Homocysteinylated Proteins

   • Hieronim Jakubowski

   Pages 121-135

9. Back Matter

   Pages 137-166

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Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease. ​

• genetic hyperhomocysteinemia
• homocysteine
• methionine metabolism
• Protein Structure
• metabolic disease

• Department of Microbiology and Molecular, UMDNJ-New Jersey Medical School, International Center for Public Health, NEWARK, USA

  Hieronim Jakubowski

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