Physiology and Pharmacology of Bone

1. Front Matter

   Pages I-XXV

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2. Calcium Homeostasis

   • A. M. Parfitt

   Pages 1-65

3. Bone Remodeling and Bone Structure

   • E. F. Eriksen, A. Vesterby, M. Kassem, F. Melsen, L. Mosekilde

   Pages 67-109

4. Biology of the Osteoclast

   • R. Baron, M. Chakraborty, D. Chatterjee, W. Horne, A. Lomri, J.-H. Ravesloot

   Pages 111-147

5. Osteoblasts: Differentiation and Function

   • T. J. Martin, D. M. Findlay, J. K. Heath, K. W. Ng

   Pages 149-183

6. Cytokines of Bone

   • G. R. Mundy

   Pages 185-214

7. Hormonal Factors Which Regulate Bone Resorption

   • G. R. Mundy

   Pages 215-247

8. Factors That Regulate Bone Formation

   • E. Canalis, T. L. McCarthy, M. Centrella

   Pages 249-266

9. Mineralization

   • H. C. Anderson, D. C. Morris

   Pages 267-298

10. Pathogenesis of Osteoporosis

    • L. G. Raisz, K. C. Shoukri

    Pages 299-331

11. Vitamin D Metabolism

    • J. A. Eisman

    Pages 333-375

12. Bisphosphonates: Mechanisms of Action and Clinical Use

    • H. Fleisch

    Pages 377-418

13. Paget’s Disease

    • D. C. Anderson

    Pages 419-441

14. Hyperparathyroid and Hypoparathyroid Bone Disease

    • M. Peacock

    Pages 443-483

15. Skeletal Responses to Physical Loading

    • L. E. Lanyon

    Pages 485-505

16. Parathyroid Hormone: Biosynthesis, Secretion, Chemistry, and Action

    • H. M. Kronenberg, F. R. Bringhurst, S. Nussbaum, H. Jüppner, A.-B. Abou-Samra, G. Segre et al.

    Pages 507-567

17. Calcitonin Gene Products: Molecular Biology, Chemistry, and Actions

    • W. Born, J. A. Fischer

    Pages 569-616

18. Parathyroid Hormone-Related Protein: Molecular Biology, Chemistry, and Actions

    • T. J. Martin

    Pages 617-639

19. Pathophysiology of Skeletal Complications of Cancer

    • G. R. Mundy, T. J. Martin

    Pages 641-671

20. The Proteins of Bone

    • P. D. Delmas, L. Malaval

    Pages 673-724

Why have another book in the bone-calcium field? When the idea was first raised that this important area of biomedical research should be given more attention in the review literature, we felt that comprehensive texts recently published and in press were directed at more general audiences and did not address in detail some of the important areas of current investigation. As this field has grown and matured, information has accumulated at such a rapid rate that it has become impossible to keep abreast of all areas by reading the original articles in the scientific literature. Accordingly, we believed there was a void which could be filled by a collection of essays on specific topics in which significant progress had recently been made. Thus, this book is meant to be an up-to-date account of specific topics by investi­ gators at the forefront of their areas of research. We have tried to review major areas of basic science in the field which have an impact on our understanding of the diseases of bone and mineral. We hope that you will agree that the authors have done an outstanding job, and will find the volume as stimulating to read as we have. San Antonio, TX, USA GREGORY R. MUNDY Melbourne, Australia T. JOHN MARTIN Spring 1993 Contents CHAPTER 1 Calcium Homeostasis A. M. PARFITI. With 12 Figures 1 A. Introduction and Scope. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 B. Concepts of Homeostasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 C. Extracellular Fluid Free Calcium: The Controlled Variable. . . . . .

• Calcium
• Knochen
• Osteoporose
• Osteoporosis
• Resorption
• Vitamin D
• bone
• metabolism
• pathophysiology
• physiology

• Division of Endocrinology and Metabolism Department of Medicine, The University of Texas Health Science Center, San Antonio, USA

  Gregory R. Mundy

• Department of Medicine, and St. Vincent’s Institute of Medical Research, University of Melbourne, Melbourne, Australia

  T. John Martin

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