2010

Transformative Concepts for Drug Design: Target Wrapping

Authors:

ISBN: 978-3-642-11791-6 (Print) 978-3-642-11792-3 (Online)

Table of contents (14 chapters)

  1. Front Matter

    Pages i-x

  2. No Access

    Book Chapter

    Pages 1-15

    Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy

  3. No Access

    Book Chapter

    Pages 17-26

    Wrapping Defects and the Architecture of Soluble Proteins

  4. No Access

    Book Chapter

    Pages 27-47

    Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins

  5. No Access

    Book Chapter

    Pages 49-58

    Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design

  6. No Access

    Book Chapter

    Pages 59-78

    Under-Wrapped Proteins in the Order–Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation

  7. No Access

    Book Chapter

    Pages 79-96

    Evolution of Protein Wrapping and Implications for the Drug Designer

  8. No Access

    Book Chapter

    Pages 97-115

    Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence

  9. No Access

    Book Chapter

    Pages 117-140

    Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects

  10. No Access

    Book Chapter

    Pages 141-161

    Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways

  11. No Access

    Book Chapter

    Pages 163-186

    Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact

  12. No Access

    Book Chapter

    Pages 187-196

    Inducing Folding By Crating the Target

  13. No Access

    Book Chapter

    Pages 197-210

    Wrapper Drugs as Therapeutic Editors of Side Effects

  14. No Access

    Book Chapter

    Pages 211-215

    Wrapper Drugs for Personalized Medicine

  15. No Access

    Book Chapter

    Pages 217-223

    Last Frontier and Back to the Drawing Board: Protein–Water Interfacial Tension in Drug Design

  16. Back Matter

    Pages 225-230