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Proton Pump Inhibitors

  • Book
  • © 1999

Overview

Editors:
  1. Lars Olbe

    1. Centre for Gastroenterological Research, University of Göteborg, Göteborg, Sweden

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Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-X
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  2. The discovery and development of the proton pump inhibitor

    1. Front Matter

      Pages 1-1
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    2. The discovery and development of the proton pump inhibitor

      • Sven Erik Sjöstrand, Lars Olbe, Erik Fellenius
      Pages 3-20

  3. Mechanism of Action

    1. Front Matter

      Pages 21-21
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    2. The gastric H, K ATPase

      • George Sachs, Björn Wallmark
      Pages 23-45

    3. Inhibition of the gastric proton pump

      • Björn Wallmark, George Sachs
      Pages 47-59

  4. The Pharmacology of Proton Pump Inhibitors

    1. Front Matter

      Pages 61-61
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    2. Inhibition of gastric acid secretion

      • Jia-Qing Huang, Richard H. Hunt
      Pages 63-78

    3. Consequences of gastric acid inhibition in animals

      • Enar Carlsson, Niilo Havu
      Pages 79-89

    4. Consequences of gastric acid inhibition in man

      • Werner Creutzfeldt
      Pages 91-115

    5. The acid tolerance of Helicobacter pylori

      • George Sachs, David Scott, David Wecks, Klaus Melchers
      Pages 117-130

    6. Interactions of proton pump inhibitors and Helicobacter pylori in vivo

      • Andre Louis Blum, Jan Martinek
      Pages 131-141

    7. Comparison of different proton pump inhibitors

      • Karl-Uwe Petersen
      Pages 143-157

  5. Pharmaceutical considerations

    1. Front Matter

      Pages 159-159
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    2. Pharmaceutical considerations

      • Åke G. Pilbrant
      Pages 161-169

  6. Clinical Experience with Proton Pump Inhibitors

    1. Front Matter

      Pages 171-171
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    2. Helicobacter pylori infection and peptic ulcer disease

      • Peter Malfertheiner
      Pages 173-191

    3. Non-Steroidal anti-inflammatory drug-associated ulcers

      • C. J. Hawkey
      Pages 193-203

    4. Zollinger-Ellison syndrome

      • Robert T. Jensen
      Pages 205-221

    5. Gastro-oesophageal reflux disease

      • Lars Lundell, John Dent
      Pages 223-235
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Keywords

About this book

Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi­ bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be­ tween efficacy and safety of a new drug. This goal often involves time and many different specialists.

Editors and Affiliations

  • Centre for Gastroenterological Research, University of Göteborg, Göteborg, Sweden

    Lars Olbe

Bibliographic Information

  • Book Title: Proton Pump Inhibitors

  • Editors: Lars Olbe

  • Series Title: Milestones in Drug Therapy

  • DOI: https://doi.org/10.1007/978-3-0348-8795-3

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Verlag 1999

  • Hardcover ISBN: 978-3-7643-5897-6Published: 01 April 1999

  • Softcover ISBN: 978-3-0348-9777-8Published: 03 October 2013

  • eBook ISBN: 978-3-0348-8795-3Published: 06 December 2012

  • Series ISSN: 2296-6056

  • Series E-ISSN: 2296-6064

  • Edition Number: 1

  • Number of Pages: X, 251

  • Topics: Medicine/Public Health, general

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