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  • Book
  • © 2007

Abeta Peptide and Alzheimer's Disease

Celebrating a Century of Research

  • Targeted specifically at summarizing current knowledge of the Abeta peptide and its role in Alzheimer’s disease

  • Includes supplementary material: sn.pub/extras

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
  2. The Aβcentric Pathway of Alzheimer’s Disease

    • Victor L. Villemagne, Roberto Cappai, Kevin J. Barnham, Robert A. Cherny, Carlos Opazo, Kathy E. Novakovic et al.
    Pages 5-36
  3. The Function of the Amyloid Precursor Protein Family

    • Roberto Cappai, B. Elise Needham, Giuseppe D. Ciccotosto
    Pages 37-51
  4. The Involvement of Aβ in the Neuroinflammatory Response

    • Piet Eikelenboom, Willem A. van Gool, Annemieke J. M. Rozemuller, Wiep Scheper, Rob Veerhuis, Jeroen J. M. Hoozemans
    Pages 52-82
  5. Cholesterol and Alzheimer’s Disease

    • Joanna M. Cordy, Benjamin Wolozin
    Pages 142-158
  6. Amyloid β-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer’s Disease Pathology

    • Satyabrata Karn, Z. Wei, David MacTavish, Doreen Kabogo, Mee-Sook Song, Jack H. Jhamandas
    Pages 159-178
  7. Physiologic and Neurotoxic Properties of Aβ Peptides

    • Gillian C. Gregory, Claire E. Shepherd, Glenda M. Halliday
    Pages 179-197
  8. Impact of β-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models

    • Jürgen Götz, Della C. David, Lars M. Ittner
    Pages 198-215
  9. Glial Cells and Aβ Peptides in Alzheimer’s Disease Pathogenesis

    • Gilbert Siu, Peter Clifford, Mary Kosciuk, Venkat Venkataraman, Robert G. Nagele
    Pages 216-233
  10. Mouse Models of Alzheimer’s Disease

    • Dwight C. German
    Pages 259-273
  11. Back Matter

    Pages 274-298

About this book

Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). Abeta Peptide and Alzheimer’s Disease is specifically targeted at summarizing current knowledge of the Abeta peptide and its role in AD.

Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta. Although specifically focusing on the Abeta peptide and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinsons and Huntingtons. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases.

Editors and Affiliations

  • Research and Development, Ocean Nutrition Canada, Dartmouth, Canada

    Colin J. Barrow

  • Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

    David H. Small

Bibliographic Information

  • Book Title: Abeta Peptide and Alzheimer's Disease

  • Book Subtitle: Celebrating a Century of Research

  • Editors: Colin J. Barrow, David H. Small

  • DOI: https://doi.org/10.1007/978-1-84628-440-3

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London 2007

  • Hardcover ISBN: 978-1-85233-961-6Published: 18 December 2006

  • Softcover ISBN: 978-1-4471-6234-6Published: 20 September 2014

  • eBook ISBN: 978-1-84628-440-3Published: 22 December 2006

  • Edition Number: 1

  • Number of Pages: XI, 298

  • Topics: Neurology, Neurosurgery, Medical Biochemistry, Neurosciences, Molecular Medicine, Human Genetics

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access