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Bioinformatics and Drug Discovery

  • Book
  • © 2012

Overview

Editors:
  1. Richard S. Larson

    1. , Department of Pathology, The University of New Mexico, Albuquerque, USA

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  • Contains fully updated protocols on the cutting-edge of the field's progress
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 910)

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Table of contents (15 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Cell Perturbation Screens for Target Identification by RNAi

    • Kubilay Demir, Michael Boutros
    Pages 1-13

  3. Using Functional Genomics to Identify Drug Targets: A Dupuytren’s Disease Example

    • Mirela Sedic, Sandra Kraljevic Pavelic, Karlo Hock
    Pages 15-31

  4. Functional Characterization of Human Genes from Exon Expression and RNA Interference Results

    • Dorothea Emig, Hagen Blankenburg, Fidel Ramírez, Mario Albrecht
    Pages 33-53

  5. Barcode Sequencing for Understanding Drug–Gene Interactions

    • Andrew M. Smith, Tanja Durbic, Saranya Kittanakom, Guri Giaever, Corey Nislow
    Pages 55-69

  6. High-Throughput Sequencing of the Methylome Using Two-Base Encoding

    • Christina A. Bormann Chung
    Pages 71-86

  7. Applications and Limitations of In Silico Models in Drug Discovery

    • Ahmet Sacan, Sean Ekins, Sandhya Kortagere
    Pages 87-124

  8. Compound Collection Preparation for Virtual Screening

    • Cristian G. Bologa, Tudor I. Oprea
    Pages 125-143

  9. Mapping Between Databases of Compounds and Protein Targets

    • Sorel Muresan, Markus Sitzmann, Christopher Southan
    Pages 145-164

  10. Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-array and Gene Expression Data

    • N. Sukumar, Michael P. Krein, Mark J. Embrechts
    Pages 165-194

  11. Advances in Nuclear Magnetic Resonance for Drug Discovery

    • Laurel O. Sillerud, Richard S. Larson
    Pages 195-266

  12. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance

    • Toshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami
    Pages 267-278

  13. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection

    • Javier De Las Rivas, Carlos Prieto
    Pages 279-296

  14. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network Analysis

    • Benjamin J. Keller, Sebastian Martini, Viji Nair
    Pages 297-308

  15. Models of Excitation–Contraction Coupling in Cardiac Ventricular Myocytes

    • M. Saleet Jafri
    Pages 309-335

  16. Integration of Multiple Ubiquitin Signals in Proteasome Regulation

    • Marta Isasa, Alice Zuin, Bernat Crosas
    Pages 337-370

  17. Back Matter

    Pages 371-374
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Keywords

About this book

Recent advances in drug discovery have been rapid.  The second edition of  Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter,  detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition  seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

Editors and Affiliations

  • , Department of Pathology, The University of New Mexico, Albuquerque, USA

    Richard S. Larson

Bibliographic Information

  • Book Title: Bioinformatics and Drug Discovery

  • Editors: Richard S. Larson

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-61779-965-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2012

  • Hardcover ISBN: 978-1-61779-964-8Published: 21 July 2012

  • Softcover ISBN: 978-1-4939-5929-7Published: 23 August 2016

  • eBook ISBN: 978-1-61779-965-5Published: 23 July 2012

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XII, 374

  • Topics: Bioinformatics, Pharmacy

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