Gene Therapy for Cancer

1. Front Matter

   Pages i-xi

   PDF

2. Vectors

   1. Front Matter

      Pages 1-1

      PDF

   2. Adenovector-Mediated Cancer Gene Therapy

      • Bingliang Fang, Jack A. Roth

      Pages 3-22

   3. Efficacy, Toxicity, and Immunogenicity of Adenoviral Vectors

      • Dmitry M. Shayakhmetov

      Pages 23-38

   4. Lentiviral and Retroviral Vector Systems

      • Renata Stripecke, Noriyuki Kasahara

      Pages 39-71

   5. Vaccinia and Pox-Virus

      • Sricharan Chalikonda, David L. Bartlett

      Pages 73-85

   6. Herpes Simplex Virus as a Therapy for Cancer

      • Ian J. Mohr

      Pages 87-108

   7. Alphavirus Vectors for Gene Therapy Applications

      • Kenneth Lundstrom

      Pages 109-119

   8. Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors

      • Glen N. Barber

      Pages 121-140

   9. Parvovirus Vectors

      • Selvarangan Ponnazhagan

      Pages 141-155

   10. Nonviral Vector Systems

       • Pui-yan Lee, Leaf Huang

       Pages 157-170

3. Gene Therapy Approaches

   1. Front Matter

      Pages 171-171

      PDF

   2. Oncogenes, Tumor Suppressor Genes and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy

      • Lidong Zhang, Bingliang Fang

      Pages 173-184

   3. Gene Silencing Therapy Against Cancer

      • Chao-Zhong Song

      Pages 185-196

   4. Tumor Targeting-Retargeted Adenovirus

      • Masato Yamamoto, David T. Curiel

      Pages 197-212

   5. Oncolytic Herpes Simplex for Gene Therapy in Preclinical and Clinical Trials

      • Richard H. Pin, Maura Reinblatt, Yuman Fong, William R. Jarnagin

      Pages 213-222

   6. Cytokine Gene Therapy for Genitourinary Cancer

      • Terry L. Timme, Tetsuo Fujita, Hongyu Wang, Koji Naruishi, Dov Kadmon, Robert J. Amato et al.

      Pages 223-241

   7. Combination of Gene Therapy with Radiation

      • Anupama Munshi, Raymond E. Meyn

      Pages 243-256

   8. Gene Transfer for Chemoprotection and Enrichment of Hematopoietic Stem Cells

      • Justin C. Roth, Stanton L. Gerson

      Pages 257-279

   9. Nonviral Genetic Vaccines for Cancer

      • Steven R. Little, Daniel G. Anderson, Robert S. Langer

      Pages 281-300

The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes. Unlike the treatment of genetic defects, where expr- sion of the corrected gene needs to be strong, permanent and, sometimes regulated, tactics to treat tumors can be based on temporary and locally limited effects. In addition, cancer cells have different properties than normal cells and this allows for targeting gene therapy to specific cells, a major advantage over current antitumor therapies, which are also toxic to normal cells and tissues.

• angiogenesis
• apoptosis
• cancer treatment
• clinical trial
• gene therapy
• gene transfer
• hematopoietic stem cell
• immune system
• metastasis
• ovarian cancer
• stem cells
• tumor

From the reviews:

"The book is divided into 3 sections. … this book is informative and provides a comprehensive review of the advances and limitations of cancer gene therapy. … Overall, the book provides enjoyable and instructive reading material. I highly recommend this book to scientists as well as clinicians as a reference source for cancer gene therapy. Readers would benefit from this excellent reading material, whether they are relatively new to this subspecialty or are actively working within the field of cancer gene therapy." (Prem Seth, JAMA, Vol. 299 (11), 2008)

"Gene Therapy for Cancer … covers the current technologies of cancer gene therapy as well as the difficult task of applying these in clinical trials. … The book also benefits through its helpful tables, drawings and illustrations. … Gene Therapy for Cancer provides a good overview of currently available techniques for cancer gene therapy and their limitations and potential for clinical applications. The book is a useful addition to the library of both researchers and clinicians working in the field." (S. Schepelmann and C. J. Springer, British Journal of Cancer, Vol. 98 (3), 2008)

“This new volume in Humana’s series is written for oncologists, hematologists, cancer researchers, geneticists.” (Tumori, Vol. 93, 2007)

• The University of Texas M. D. Anderson Cancer Center, Houston

  Kelly K. Hunt, Stephen G. Swisher

• Inselspital Bern, University of Bern, Bern, Switzerland

  Stephan A. Vorburger

Policies and ethics