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Hybridomas and Cellular Immortality

  • Book
  • © 1983

Overview

Editors:
  1. Baldwin H. Tom

    1. Medical School at Houston, University of Texas, Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. James P. Allison

    1. System Cancer Center, University of Texas, Smithville, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (41 chapters)

  1. Front Matter

    Pages i-xx
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  2. Introduction to Hybridomas

    1. Front Matter

      Pages 1-1
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    2. Somatic Cell Hybrids and Hybridomas

      • Baldwin H. Tom
      Pages 3-11

  3. Antibody Diversity and Lymphocyte Differentiation

    1. Front Matter

      Pages 13-13
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    2. The Nature and Origin of Antibody Diversity

      • Paul D. Gottlieb
      Pages 15-26

    3. Hematopoietic Tumors: Normal or Abnormal Models of Leukocyte Differentiation?

      • Noel L. Warner, Lewis L. Lanier, Edwin Walker, Carlton Stewart, Gary Wood, Charles Balch
      Pages 27-44

    4. Dissection of Human Immunoregulatory T Lymphocytes: Implications for Understanding Clinical Disease

      • Ellis L. Reinherz, Chikao Morimoto, Stefan Meuer, Stuart F. Schlossman
      Pages 45-66

    5. Immune (γ) Interferon and Lymphotoxin Production by T Cell Lines and Hybrids

      • Nancy H. Ruddle, Barbara S. Conta
      Pages 67-79

  4. Monoclonal Antibodies as Probes of Antigen Structure

    1. Front Matter

      Pages 81-81
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    2. Partial Structural Characterization of Human HLA-DR Subsets Using Monoclonal Antibodies

      • Carolyn Katovich Hurley, Gabriel Nunez, Robert Winchester, Olja Finn, Ronald Levy, Peter Stastny et al.
      Pages 83-100

    3. Monoclonal Antibodies for Analysis of HLA Antigens: Further Studies with the W6/32 Antibody

      • Peter Parham, Harry T. Orr, John S. Golden
      Pages 101-123

  5. Monoclonal Antibodies in Diagnosis and Therapy

    1. Front Matter

      Pages 125-125
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    2. Monoclonal Antibodies to Hepatitis B Surface Antigen

      • Vincent R. Zurawski Jr., Nancy T. Chang
      Pages 127-143

    3. Wandering Around the Cell Surface — Monoclonal Antibodies Against Human Neuroblastoma and Leukemia Cell Surface Antigens

      • Madelyn Feder, Zdenka L. Jonak, Arthur A. Smith, Mary Catherine Glick, Roger H. Kennett
      Pages 145-158

    4. Monoclonal Antibodies to Human Melanoma-Associated Antigen p97

      • Joseph P. Brown, Karl Erik Hellström, Ingegerd Hellstrom
      Pages 159-169

    5. A Biochemical and Biosynthetic Analysis of Human Melanoma-Associated Antigens with Monoclonal Antibodies

      • Thomas F. Bumol, John R. Harper, Darwin O. Chee, Ralph A. Reisfeld
      Pages 171-184

    6. Monoclonal Antibodies to a Tumor Specific Antigen on Rat Mammary Carcinoma Sp4 and Their Use in Drug Delivery Systems

      • R. W. Baldwin, M. J. Embleton, G. R. Flannery, B. Gunn, J. A. Jones, J. G. Middle et al.
      Pages 185-200

    7. Monoclonal Antibody to Tumor Specific Epitope of Murine Lymphoma Cells: Use in Characterization of Antigen and in Immunotherapy

      • James P. Allison, Bradley W. McIntyre, James Irvin, David Bloch, Garrie B. Kitto
      Pages 201-220

  6. New and Relevant Methodology

    1. Front Matter

      Pages 221-221
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    2. Human Hybridomas

      • Carlo M. Croce
      Pages 223-233
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Keywords

About this book

The ability to "immortalize" immunologically-useful cells by hybridization with a unique cancer cell has revolutionized serological studies and has revealed new potential applications in all fields of biological sciences. This volume presents the studies from a highly successful national symposium on Hybridomas and Cellular Immortality held November 1981 in Houston, Texas. The individual chapters exhibit the diversity of topics discussed during the meeting. These include emphasis on the origin of antibody diversity, Band T lymphocyte differentiation, applications of monoclonal antibodies in studies of histocompatibility, tumor, and viral antigens, plus the use of somatic cell hybridizations for studying T cell products. Three papers focus on the emerging methodologies of in vitro primary immunizations for both humoral and cell-mediated immunities, relevant for coupling with hybridoma technology. There is a useful mix of general (methods) and specific (applications) chapters. A unique aspect of the book is the presentation of both recent research findings with concise descriptions of the state of the art methodologies. It is anticipated that this work will be of interest to a wide audience of practioners in biomedical research. Hopefully, the information contained will foster new and imagi­ native ideas in hybridoma applications. Baldwin H. Tom, Ph.D. James P. Allison, Ph.D. vii CONTENTS PART L INTRODUCTION TO HYBRIDOMAS 1 Somatic Cell Hybrids and Hybridomas Baldwin H. Tom 3 1. Somatic Cell Hybrids 8 Hybridomas. • • • • • 2.

Editors and Affiliations

  • Medical School at Houston, University of Texas, Houston, USA

    Baldwin H. Tom

  • System Cancer Center, University of Texas, Smithville, USA

    James P. Allison

Bibliographic Information

  • Book Title: Hybridomas and Cellular Immortality

  • Editors: Baldwin H. Tom, James P. Allison

  • DOI: https://doi.org/10.1007/978-1-4615-9352-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1983

  • Softcover ISBN: 978-1-4615-9354-6Published: 09 February 2012

  • eBook ISBN: 978-1-4615-9352-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XX, 306

  • Topics: Anatomy

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