Name: Detection of Mitochondrial Diseases
ISBN: 978-1-4615-6111-8

Editors:

Frank Norbert Gellerich⁰,
Stephan Zierz¹

Frank Norbert Gellerich
1. Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany
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Stephan Zierz
1. Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany
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Part of the book series: Developments in Molecular and Cellular Biochemistry (DMCB, volume 21)

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Table of contents (50 chapters)

Front Matter

Pages i-3

PDF
Noninvasive Detection of Mitochondrial Function
1. Front Matter
  
  Pages 4-4
  
  PDF
2. Diagnosis of defects in oxidative muscle metabolism by non-invasive tissue oximetry
  
  William Bank, Britton Chance
  
  Pages 7-10
3. In vivo assessment of human skeletal muscle mitochondria respiration in health and disease
  
  Bruno Barbiroli, Stefano Iotti, Raffaele Lodi
  
  Pages 11-15
4. Non-invasive quantitative ³¹P MRS assay of mitochondrial function in skeletal muscle in situ
  
  Jeroen A. L. Jeneson, Robert W. Wiseman, Martin J. Kushmerick
  
  Pages 17-22
5. Phosphorus metabolite distribution in skeletal muscle: Quantitative bioenergetics using creatine analogs
  
  Robert W. Wiseman, M. J. Kushmerick
  
  Pages 23-28
6. A theoretical model of some spatial and temporal aspects of the mitochondrion creatine kinase myofibril system in muscle
  
  G. J. Kemp, D. N. Manners, J. F. Clark, M. E. Bastin, G. K. Radda
  
  Pages 29-32
7. Fluxes through cytosolic and mitochondrial creatine kinase, measured by P-31 NMR
  
  Ferdi A. van Dorsten, Torsten Reese, Johannes F. Gellerich, Cees J. A. van Echteld, Marcel G. J. Nederhoff, Henk-Jan Muller et al.
  
  Pages 33-42
8. Experimental evidence for dynamic compartmentation of ADP at the mitochondrial periphery: Coupling of mitochondrial adenylate kinase and mitochondrial hexokinase with oxidative phosphorylation under conditions mimicking the intracellular colloid osmotic pressure
  
  Fanny Dorine Laterveer, Klaas Nicolay, Frank Norbert Gellerich
  
  Pages 43-51
Bioenergetic Investigation of Isolated Mitochondria, Skinned Muscle Fibers and Cells
1. Front Matter
  
  Pages 53-53
  
  PDF
2. Small scale preparation of skeletal muscle mitochondria, criteria of integrity, and assays with reference to tissue function
  
  Hans N. Rasmussen, Ulla F. Rasmussen
  
  Pages 55-60
3. Rapid isolation of muscle and heart mitochondria, the lability of oxidative phosphorylation and attempts to stabilize the process in vitro by taurine, carnitine and other compounds
  
  Hans R. Scholte, Yihong Yu, John D. Ross, Imma I. Oosterkamp, Adriana M. C. Boonman, F. M. Busch
  
  Pages 61-66
4. Tetraphenylphosphonium inhibits oxidation of physiological substrates in heart mitochondria
  
  Vida Mildaziene, Rasa Baniene, Ausra Marcinkeviciute, Zita Nauciene, Alvydas Kalvenas, Aurelijus Zimkus
  
  Pages 67-70
5. High resolution respirometry of permeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders
  
  Wolfgang Sperl, Daniela Skladal, Erich Gnaiger, Markus Wyss, Udo Mayr, Josef Hager et al.
  
  Pages 71-78
6. Detection of early ischemic damage by analysis of mitochondrial function in skinned fibers
  
  Laurence Kay, André Rossi, Valdur Saks
  
  Pages 79-85
7. The effects of ischemia and experimental conditions on the respiration rate of cardiac fibers
  
  Adolfas Toleikis, Daiva Majiene, Sonata Trumbeckaite, Arvydas Dagys
  
  Pages 87-90
8. Insulin as a probe of mitochondrial metabolism in situ
  
  Samuel P. Bessman, Chandra Mohan
  
  Pages 91-96
9. Detection of mitochondrial defects by laser fluorimetry
  
  Wolfram S. Kunz, Kirstin Winkler, Andrey V. Kuznetsov, Hartmut Lins, Elmar Kirches, Claus W. Wallesch
  
  Pages 97-100
10. Oxidative phosphorylation in myocardial mitochondria ‘in situ’: a calorimetric study on permeabilized cardiac muscle preparations
  
  Detlef Köhnke, Marion Schramm, Jürgen Daut
  
  Pages 101-113
11. Nicotinamide adenine dinucleotides permeate through mitochondrial membranes in human Epstein-Barr virus-transformed lymphocytes
  
  P. Rustin, D. Chretien, B. Parfait, A. Rötig, A. Munnich
  
  Pages 115-119

About this book

In October 1995, the 1st Colloquium on Mitochondria and Myopathies in Halle/Saale was organized in Halle/Saale by the editors of this focused issue. The meeting took up what might be called an East German tradition: from 1976 to 1990 Andreas Schmidt organized seven clinically orientated Colloquia on Myology in Jena, and from 1974 to 1990 a series of twelve Colloquia on Mitochondria focused on basic research aspects was arranged by Wolfgang Kunz in Magdeburg. At those meetings, East Germany was a mediator between East European, West European and American scientists. In continuation of this tradition, scientists from more than 17 countries working on mitochondria as neurologists, biochemists, geneticists, or as physiologists came to Halle. The title of the colloquium indicated the combination of both basic and clinical mitochondrial research. The most important contributions of this meeting are now published in this focused issue. We thank all authors for their patience and cooperation that have made it possible to produce this unique collection of papers representing current knowledge on detection of mitochondrial causes of diseases. We especially thank Prof. N.S. Dhalla for making it possible to publish these contributions together in this focused issue and also as a hard-cover book.

Keywords

Editors and Affiliations

Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany

Frank Norbert Gellerich, Stephan Zierz

Bibliographic Information

Book Title: Detection of Mitochondrial Diseases
Editors: Frank Norbert Gellerich, Stephan Zierz
Series Title: Developments in Molecular and Cellular Biochemistry
DOI: https://doi.org/10.1007/978-1-4615-6111-8
Publisher: Springer New York, NY
eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media Dordrecht 1997
Hardcover ISBN: 978-0-7923-9925-4Published: 30 September 1997
Softcover ISBN: 978-1-4613-7800-6Published: 13 October 2012
eBook ISBN: 978-1-4615-6111-8Published: 06 December 2012
Edition Number: 1
Number of Pages: VI, 341
Additional Information: Reprinted from MOLECULAR AND CELLULAR BIOCHEMISTRY, 174:1-2
Topics: Biochemistry, general

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Detection of Mitochondrial Diseases

Editors:

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Table of contents (50 chapters)

Front Matter

Noninvasive Detection of Mitochondrial Function

Front Matter

Diagnosis of defects in oxidative muscle metabolism by non-invasive tissue oximetry

In vivo assessment of human skeletal muscle mitochondria respiration in health and disease

Non-invasive quantitative ³¹P MRS assay of mitochondrial function in skeletal muscle in situ

Phosphorus metabolite distribution in skeletal muscle: Quantitative bioenergetics using creatine analogs

A theoretical model of some spatial and temporal aspects of the mitochondrion creatine kinase myofibril system in muscle

Fluxes through cytosolic and mitochondrial creatine kinase, measured by P-31 NMR

Experimental evidence for dynamic compartmentation of ADP at the mitochondrial periphery: Coupling of mitochondrial adenylate kinase and mitochondrial hexokinase with oxidative phosphorylation under conditions mimicking the intracellular colloid osmotic pressure

Bioenergetic Investigation of Isolated Mitochondria, Skinned Muscle Fibers and Cells

Front Matter

Small scale preparation of skeletal muscle mitochondria, criteria of integrity, and assays with reference to tissue function

Rapid isolation of muscle and heart mitochondria, the lability of oxidative phosphorylation and attempts to stabilize the process in vitro by taurine, carnitine and other compounds

Tetraphenylphosphonium inhibits oxidation of physiological substrates in heart mitochondria

High resolution respirometry of permeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders

Detection of early ischemic damage by analysis of mitochondrial function in skinned fibers

The effects of ischemia and experimental conditions on the respiration rate of cardiac fibers

Insulin as a probe of mitochondrial metabolism in situ

Detection of mitochondrial defects by laser fluorimetry

Oxidative phosphorylation in myocardial mitochondria ‘in situ’: a calorimetric study on permeabilized cardiac muscle preparations

Nicotinamide adenine dinucleotides permeate through mitochondrial membranes in human Epstein-Barr virus-transformed lymphocytes

About this book

Keywords

Editors and Affiliations

Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany

Bibliographic Information

Publish with us

Buy it now

Other ways to access

Navigation

Editors:

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Buy it now

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Other ways to access

Table of contents (50 chapters)

Front Matter

Noninvasive Detection of Mitochondrial Function

Front Matter

Bioenergetic Investigation of Isolated Mitochondria, Skinned Muscle Fibers and Cells

Front Matter

About this book

Keywords

Editors and Affiliations

Martin Luther Universität Halle-Wittenberg, Neurologische Klinik und Poliklinik, Halle / Saale, Germany

Bibliographic Information

Publish with us

Buy it now

Buying options

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