Androgens and Androgen Receptor

1. Front Matter

   Pages i-xiv

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2. Androgen Biosynthesis And Degradation

   • Bon-chu Chung, Meng-Chun Hu

   Pages 1-15

3. Structural and Functional Analysis of the Androgen Receptor

   • Cynthia A. Heinlein, Chawnshang Chang

   Pages 17-55

4. Signal Transduction Pathways Modulate Androgen Receptor Transcriptional Activity

   • Cynthia A. Heinlein, Chang Chawnshang

   Pages 57-90

5. Androgen Receptor Interacting Proteins: Co-Activators And Co-Repressors

   • Cynthia A. Heinlein, Erik R. Sampson, Chang Chawnshang

   Pages 91-138

6. Nongenomic Androgen Action

   • Cynthia A. Heinlein, Chang Chawnshang

   Pages 139-154

7. The Role of 5α-Reductase in Prostate Disease and Male Pattern Baldness

   • Jun Shimazaki

   Pages 155-196

8. Natural Products and Environmental Androgens/Antiandrogens

   • Wang Ming-Hsien, Yeh Shuyuan, Su Ching-Yuan, Young Charles Y. F.

   Pages 197-211

9. Androgens in Prostate Cancer and Benign Prostatic Hyperplasia

   • Terry R. Brown

   Pages 213-243

10. The Expanded Poly-Q Length Within AR and AR Coregulator AIB1 and Their Clinical Implications

    • Ann W. Hsing, Zoran Culig, Chang Chawnshang

    Pages 245-264

11. Androgen Receptor with Expanded Poly-Q Length in SBMA (Kennedy Disease)

    • Kobayashi Yasushi, Sobue Gen

    Pages 265-270

12. Androgen Insensitivity Syndrome (Testicular Feminization)

    • Hajime Nawata, Goto Kiminobu, Okabe Taijiro, Nomura Masatoshi, Yanase Toshihiko

    Pages 271-277

13. Androgens in Immunology and Autoimmune Diseases

    • Nancy J. Olsen, William J. Kovacs

    Pages 279-288

14. Androgens in Penile Development, Penile Erection, and Erectile Dysfunction

    • Johnny A. Chang, Nguyen Hiep T., Tom F. Lue

    Pages 289-298

15. Androgens and the Androgen Receptor in Male Sex Development and Fertility

    • Loretta L. Collins, Chang Chawnshang

    Pages 299-323

16. Androgens and Brain Function: Behavioral Perspectives

    • Robert J. Handa, Robert F. McGivern

    Pages 325-344

17. Androgens, Skeletal Homeostasis, and Osteoporosis

    • D. Vanderschueren, L. Vandenput, A. Verstuyf, JV. Swinnen, R. Bouillon, S. Boonen

    Pages 345-359

18. Androgens and Coronary Artery Disease

    • Arnold von Eckardstein, Fredrick C. W. Wu

    Pages 361-386

19. Androgen Therapy in Nonendocrine Illnesses

    • Daniel Spratt

    Pages 387-409

20. Androgens and Androgen Receptor in Dermatology

    • Hideo Uno, Satoshi Itami, Shigeki Inui, Huei-Ju Pan, Eugene Chang, Susumu Takayasu et al.

    Pages 411-476

Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications.
Key topics covered include:

-The discovery and cloning of the androgen receptor;
-Androgen receptor coregulators;
-Androgen related genes and their consensus DNA response elements;
-Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies;
-Cross-talk to other signal transduction systems;
-The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer.

This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.

• DNA
• autoimmune disease
• cancer
• dermatology
• endocrinology
• erectile dysfunction
• fertility
• oncology
• ovarian cancer
• prostate cancer
• sex
• therapy
• urology

• University of Rochester Medical Center, UK

  Chawnshang Chang

Chawnshang Chang, Ph.D., is the George Hoyt Whipple Distinguished Professor at the University of Rochester.

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