Cancer Targeted Drug Delivery

1. Front Matter

   Pages i-xvii

   PDF

2. History of Cancer Targeting Efforts

   1. Front Matter

      Pages 1-1

      PDF

   2. A Time Travel Journey Through Cancer Therapies

      • Ana S. Cravo, Randall J. Mrsny

      Pages 3-35

   3. Nanotechnology for Cancer Treatment: Possibilities and Limitations

      • Joseph W. Nichols, You Han Bae

      Pages 37-56

3. Targeting Issues

   1. Front Matter

      Pages 57-57

      PDF

   2. Vascular Targeting Approaches to Treat Cancer

      • Joseph W. Wragg, Roy Bicknell

      Pages 59-95

   3. Tumor Immunotherapy by Utilizing a Double-Edged Sword, Chemokines

      • Naofumi Mukaida, So-ichiro Sasaki, Tomohisa Baba

      Pages 97-118

4. General Tumor Physiology and Microenvironment Issues

   1. Front Matter

      Pages 119-119

      PDF

   2. Cancer Biology: Some Causes for a Variety of Different Diseases

      • Abood Okal, Shams Reaz, Carol S. Lim

      Pages 121-159

   3. Cancer Stromal Targeting (CAST) Therapy and Tailored Antibody Drug Conjugate Therapy Depending on the Nature of Tumor Stroma

      • Yasuhiro Matsumura, Masahiro Yasunaga, Shino Manabe

      Pages 161-181

   4. Cancer Cell Respiration: Hypoxia and pH in Solid Tumors

      • Dong Yun Lee, Taiyoun Rhim, Minhyung Lee

      Pages 183-206

   5. Tumor Vasculature, EPR Effect, and Anticancer Nanomedicine: Connecting the Dots

      • Sebastien Taurin, Hayley Nehoff, Thalita van Aswegen, Khaled Greish

      Pages 207-239

   6. Pressure Gradients in Solid Tumors

      • Shawn Stapleton, Michael F. Milosevic

      Pages 241-272

   7. The ADAMs: New Therapeutic Targets for Cancer?

      • M. J. Duffy, M. Mullooly, J. Crown, P. M. McGowan

      Pages 273-287

   8. Role of the Extracellular Matrix: Enzyme Activities and Metastasis

      • Il-Kyu Choi, Chae-Ok Yun

      Pages 289-307

   9. The Role of Non-cancerous Cells in Cancer: Pancreatic Ductal Adenocarcinoma as a Model to Understand the Impact of Tumor Microenvironment on Epithelial Carcinogenesis

      • Mert Erkan, Tania Brocks, Helmut Friess

      Pages 309-333

5. The Dynamic Problem of Tumor Heterogeneity

   1. Front Matter

      Pages 335-335

      PDF

   2. Heterogeneity of Cancers and Its Implication for Targeted Drug Delivery

      • Tracy A. Denison, You Han Bae

      Pages 337-362

   3. A Study of Cancer Heterogeneity: From Genetic Instability to Epigenetic Diversity in Colorectal Cancer

      • Maria Giovanna Francipane, Eric Lagasse

      Pages 363-388

   4. Nanotherapeutics in Multidrug Resistance

      • Min Han, Jian-Qing Gao

      Pages 389-412

This book was conceived from a simple question as to why cancer is so difficult to treat.  Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future.  This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors.  This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications.  The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications.  The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications.  Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.

• Cancer
• Cancer cells
• Cancer tharapy
• Drug delivery
• Tumor
• Tumor heterogeneity

• Pharmacutics & Pharmacutical Chemistry, University of Utah, Salt Lake City, USA

  You Han Bae

• Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath, United Kingdom

  Randall J. Mrsny

• Department of Biomedical Engineering, Purdue University, West Lafayette, USA

  Kinam Park

Professor You Han Bae

      Professor You Han Bae received his Ph.D. in 1988 from University of Utah.  He has background of chemical engineering and polymer science/engineering and pharmaceutical chemistry. He served University of Utah as a postdoctoral fellow and research assistant/associate professor till 1994. He joined the Department of Materials Science and Engineering at Gwangju Institute of Science and Technology (GIST) in Korea in 1994 as an associate professor and promoted to a full Professor in 1998. After serving 7.5 years at GIST, he came back to the University of Utah as a full professor in 2002.

      He researched stimuli sensitive polymers and drug delivery, protein drug stabilization and controlled release, and functionalized polymers for glucose sensor and biohybrid artificial pancreas. His current research interests include nanoparticulates for multidrug resistance in cancer and tumor heterogeneity, novel carrier design for the delivery of genetic materials and preclinical cancer models. He is the author or co-author of over 240 peer-reviewed scientific papers, book chapters and U.S. Patents which have been cited more than 14,000 times.

      He is an editorial board member of Pharmaceutical Research and Bioconjugate, and is also currently serving the Journal of Controlled Release (JCR) as an America Associate Editor as well as the Editor of the Concept Paper in JCR.

 

 

Professor Randall Mrsny

      Professor Randall Mrsny received his Ph.D. degree in Human Anatomy and Cell Biology from the University of California at Davis in 1981 where he was an NIH predoctoral fellow.  He was awarded an NIH postdoctoral fellowship that he undertook at the Institute of Molecular Biology at the University of Oregon where he focused on research in Membrane Biophysics. Professor Mrsny then joined ALZA Corporation where he led the Peptide Biology Group and then moved to Genentech where he led the Drug Delivery / Biology group.  In 2000 he left Genentech to start two separated biotech companies and take a part-time Professor of Drug Delivery post at Cardiff University. In 2009 he moved to the Department of Pharmacy and Pharmacology at the University of Bath where he now holds a full-time Professor of Epithelial Biology post.

      Professor Mrsny's research has focused primarily on understanding biological barriers of the body that limit or modulate the delivery of biopharmaceuticals using a multi-disciplinary approach. His current research includes the identification of vesicular trafficking pathways in epithelial hijacked cells that are by bacterial toxins, mechanism epithelial cells to regulate the transmigration of neutrophils, and protein-protein contacts involving tight junction elements that control paracellular permeability properties of epithelia. He has published more than 90 peer-reviewed papers, 25 book chapters and reviews, and presented more than 100 abstracts at national and international meetings.  He co-authored and co-edited 5 books in the area of controlled drug delivery. He is the founder of Unity Pharmaceuticals and Applied Molecular Transport.

 

 

Professor Kinam Park

      Professor Kinam Park received his Ph.D. degree in pharmaceutics from University of Wisconsin in 1983.  After a postdoctoral training at the Department of Chemical Engineering of the same university, he joined the faculty of the Purdue University in 1986 and promoted to Full Professor of Pharmaceutics in 1994. Since 1998, he has held a joint appointment in Department of Biomedical Engineering, and became Showalter Distinguished Professor of Biomedical Engineering in 2006.  

            His research has been focused on the use of various polymers and hydrogels for controlled drug delivery. His current research includes hydrogel template methods for fabrication of homogeneous microparticles for long-term drug delivery, hydrotropic polymeric micelles for increasing the water solubility of poorly soluble drugs, hydrogels for biomedical applications, and drug-eluting stents and balloons.   He has published more than 230 peer-reviewed papers, 90 book chapters, 90 JCR cover stories, and presented 200 abstracts at national and international meetings.  He co-authored and co-edited 11 books in the area of controlled drug delivery, and has trained more than 100 Ph.D. graduate students, postdoctoral fellows and visiting scientists. He is the founder of Akina, Inc. specializing in drug delivery technologies in 2001.  He is currently the Editor-in-Chief of the Journal of Controlled Release.

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