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Human Cell Transformation

Role of Stem Cells and the Microenvironment

  • Book
  • © 2012

Overview

Editors:
  1. Johng S. Rhim

    1. Uniformed Services, Department of Surgery, University of the Health Sciences, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Richard Kremer

    1. , Department of Medicine, McGill University Health Centre, Montreal, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Highlights the latest findings on the current state of human cell transformation model systems
  • Provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells
  • Covers all recently developed novel human cell models
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 720)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xxii
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  2. Multistep Models

    1. Front Matter

      Pages 1-1
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    2. Nuclear Barrier Hypothesis of Aging as Mechanism for Trade-Off Growth to Survival

      • Sang Chul Park
      Pages 3-13

    3. Establishment of Cell Lines from the Human Middle and Inner Ear Epithelial Cells

      • David J. Lim, Sung K. Moon
      Pages 15-25

    4. Cellular Systems for Studying Human Oral Squamous Cell Carcinomas

      • Vyomesh Patel, Ramiro Iglesias-Bartolome, Bradford Siegele, Christina A. Marsh, Kantima Leelahavanichkul, Alfredo A. Molinolo et al.
      Pages 27-38

    5. Heterotopic Ossification Following Musculoskeletal Trauma: Modeling Stem and Progenitor Cells in Their Microenvironment

      • Youngmi Ji, Gregory T. Christopherson, Matthew W. Kluk, Orna Amrani, Wesley M. Jackson, Leon J. Nesti
      Pages 39-50

    6. Comparative Proteomic Analysis of Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord and Placenta: Implication in the Migration

      • Guo Li, Xiao-Ai Zhang, Hua Wang, Xin Wang, Chun-Ling Meng, Chu-Yan Chan et al.
      Pages 51-68

  3. Prostate Cancer/Stem Cells

    1. Front Matter

      Pages 69-69
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    2. Novel Human Prostate Epithelial Cell Culture Models for the Study of Carcinogenesis and of Normal Stem Cells and Cancer Stem Cells

      • Johng S. Rhim, Hongzhen Li, Bungo Furusato
      Pages 71-80

    3. Prostate Tumor Cell Plasticity: A Consequence of the Microenvironment

      • Clayton Yates
      Pages 81-90

    4. Role of Epigenetics in Cancer Initiation and Progression

      • Flora Chik, Moshe Szyf, Shafaat A. Rabbani
      Pages 91-104

    5. Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms

      • Fiona M. Frame, Norman J. Maitland
      Pages 105-118

  4. Breast Cancer/ Stem Cells

    1. Front Matter

      Pages 119-119
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    2. The Role of the Basal Stem Cell of the Human Breast in Normal Development and Cancer

      • Jose Russo, Irma H. Russo
      Pages 121-134

    3. Breast Cancer Subtypes: Two Decades of Journey from Cell Culture to Patients

      • Xiangshan Zhao, Channabasavaiah Basavaraju Gurumurthy, Gautam Malhotra, Sameer Mirza, Shakur Mohibi, Aditya Bele et al.
      Pages 135-144

    4. Parathyroid Hormone Related Protein (PTHrP) in Tumor Progression

      • Richard Kremer, Jiarong Li, Anne Camirand, Andrew C. Karaplis
      Pages 145-160

  5. Multistep/Genes

    1. Front Matter

      Pages 161-161
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    2. Mechanism of Radiation Carcinogenesis: Role of the TGFBI Gene and the Inflammatory Signaling Cascade

      • Tom K. Hei, Yongliang Zhao, Hongning Zhou, Vladimir Ivanov
      Pages 163-170

    3. Histone Deacetylase Inhibitor: Antineoplastic Agent and Radiation Modulator

      • Zacharoula Konsoula, Alfredo Velena, Rachel Lee, Anatoly Dritschilo, Mira Jung
      Pages 171-179

    4. Human Fibroblasts for Large-Scale “Omics” Investigations of ATM Gene Function

      • Mira Jung, Olga Timofeeva, Amrita K. Cheema, Rency Varghese, Habtom Ressom, Anatoly Dritschilo
      Pages 181-190
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Keywords

About this book

Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells.

Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including:

·         Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems

·         Oncogenes

·         Tumor suppressor genes

·         Viral transformation

·         In vitro model systems for viral, chemical and radiation carcinogenesis

·         Cell aging

·         The multistep nature of human carcinogenesis

·         The role of stem cells and the microenvironment in tumorigenesis

·         The genes involved in multistep carcinogenesis

Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields.

Essential reading for everyone who needs to be kept up-to-date in this fast-paced area!

 

Features


Ø  Multistep models

Ø  Breast cancer/Stem cells

Ø  Prostate cancer/Stem cells

Ø  Multistep / Genes

Editors and Affiliations

  • Uniformed Services, Department of Surgery, University of the Health Sciences, Bethesda, USA

    Johng S. Rhim

  • , Department of Medicine, McGill University Health Centre, Montreal, Canada

    Richard Kremer

Bibliographic Information

  • Book Title: Human Cell Transformation

  • Book Subtitle: Role of Stem Cells and the Microenvironment

  • Editors: Johng S. Rhim, Richard Kremer

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-0254-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012

  • Hardcover ISBN: 978-1-4614-0253-4Published: 08 September 2011

  • Softcover ISBN: 978-1-4939-4164-3Published: 23 August 2016

  • eBook ISBN: 978-1-4614-0254-1Published: 15 September 2011

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXII, 224

  • Topics: Cell Biology, Stem Cells

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