Rabies

1. Front Matter

   Pages i-xiii

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2. Understanding the Nature of Rabies: An Historical Perspective

   • Lise Wilkinson

   Pages 1-23

3. Structure of Rabies Virus

   • Noel Tordo, Olivier Poch

   Pages 25-45

4. Culture of Rabies Virus in Vitro

   • Joan Crick, Arthur King

   Pages 47-66

5. Interactions of Rabies Virus and Host Cells

   • H. Tsiang

   Pages 67-100

6. The Pathogenesis of Rabies

   • K. M. Charlton

   Pages 101-150

7. Genetic Control of Resistance to Rabies

   • Donald L. Lodmell

   Pages 151-161

8. Immune Responses to Rabies Virus: Vaccines and Natural Infection

   • R. I. Macfarlan

   Pages 163-176

9. Rabies-Related Viruses

   • Arthur King, Joan Crick

   Pages 177-199

10. Diagnosis of Rabies Infection

    • W. A. Webster, G. A. Casey

    Pages 201-222

11. Serodiagnosis of Rabies: Antibody Tests

    • J. B. Campbell, L. D. Barton

    Pages 223-241

12. Epizootiology of Rabies: Eurasia and Africa

    • J. Blancou

    Pages 243-265

13. Epizootiology of Rabies: The Americas

    • Jean S. Smith, George M. Baer

    Pages 267-299

14. Persistence of Rabies in Wildlife

    • R. R. Tinline

    Pages 301-322

15. Vaccines and Vaccination of Domestic Animals

    • T. O. Bunn

    Pages 323-333

16. Development of a Vaccinia-Rabies Glycoprotein Recombinant Virus Vaccine

    • C. E. Rupprecht, M.-P. Kieny

    Pages 335-364

17. Control of Wildlife Rabies: Europe

    • Alexander I. Wandeler

    Pages 365-380

18. Control of Wildlife Rabies: The Americas

    • C. D. Macinnes

    Pages 381-405

19. Control of Urban Rabies

    • O. P. Larghi, J. C. Arrosi, J. Nakajata-A., A. Villa-Nova

    Pages 407-422

20. Errata

    • James B. Campbell, K. M. Charlton

    Pages 433-433

Rabies is an ancient disease and a fearsome one. Although it may not have the economic or public health importance of some other infectious diseases, few are so well known or carry the same emotional impact. Mainly transmitted by the bite of an enraged animal, and with practically no hope for recovery among those afflicted, it has provided the substance of stories and legends throughout the ages. The pioneering work of many 19th century workers, culminating in the development of the first rabies vaccines by Louis Pasteur, provided the ground work for the modern era in the study of rabies. Since then, and particularly in the last quarter century, considerable advances have been made in our knowledge of the nature of the infectious agent, its mode of transmission and pathogenetic mechanisms. Yet even today, much remains to be learned about the disease. For example, although effective vaccines exist for humans and other animals, there is still no known practical cure once the neurological disease symptoms develop. Markers of virulence have been mapped at the molecular level, but it is yet unclear as to how rabies virus actually exerts its pathological effects.

• animals
• antibody
• development
• diagnosis
• infection
• infectious disease
• pathogenesis
• vaccination
• vaccine
• virus

• University of Toronto, Toronto, Canada

  James B. Campbell

• Animal Diseases Research Institute, Agriculture Canada, Nepean, Canada

  K. M. Charlton

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