Frozen Section Library: Central Nervous System

1. Front Matter

   Pages i-xi

   PDF

2. Introduction

   • Richard A. Prayson, Karl M. Napekoski

   Pages 1-8

3. Where to Start

   • Richard A. Prayson, Karl M. Napekoski

   Pages 9-18

4. Nonneoplastic Flags

   • Richard A. Prayson, Karl M. Napekoski

   Pages 19-43

5. Cerebral Parenchymal Lesions: I. Metastatic Neoplasms

   • Richard A. Prayson, Karl M. Napekoski

   Pages 45-53

6. Cerebral Parenchymal Lesions: II. Primary Tumors

   • Richard A. Prayson, Karl M. Napekoski

   Pages 55-78

7. Dural-Based Tumors

   • Richard A. Prayson, Karl M. Napekoski

   Pages 79-95

8. Intraventricular Lesions

   • Richard A. Prayson, Karl M. Napekoski

   Pages 97-110

9. Cerebellar Lesions

   • Richard A. Prayson, Karl M. Napekoski

   Pages 111-120

10. Pituitary Gland and Sellar Lesions

    • Richard A. Prayson, Karl M. Napekoski

    Pages 121-129

11. Pineal Gland Lesions

    • Richard A. Prayson, Karl M. Napekoski

    Pages 131-137

12. Spinal Cord Lesions

    • Richard A. Prayson, Karl M. Napekoski

    Pages 139-143

13. Back Matter

    Pages 145-152

    PDF

Frozen section of Neuropathology-related cases is performed while the patient is undergoing surgery. Intraoperative consultation is used to help guide intraoperative management of the case and to ensure that adequate and appropriate tissue has been obtained for purposes of making an accurate final diagnosis. Frozen section diagnosis is often a highly demanding situation for the pathologist, who must render a diagnosis quickly and provide sound guidance and advice. In addition to the need for rapid recall of differential diagnoses, there are many pitfalls and artifacts that add to the risk of frozen section diagnosis that are not present with permanent sections of fully processed tissue that can be examined in a more leisurely fashion. Most standard pathology textbooks focus primarily on permanent section material and largely ignore the topic of frozen section. The purpose of this volume is to add to the Frozen Section Library series and provide a convenient, user friendly handbook to assist in the evaluation of central nervous system related frozen sections. It provides a useful reference, organized around differential diagnoses, primarily by location in the central nervous system. The text will be illustrated with color pictures and include tables as appropriate. This text provides a valuable tool for the practicing surgical pathologist both in community and in academic centers as well as pathology residents and fellows in training when confronted with Neuropathology frozen section.

From the reviews:

“This is a succinct overview of frozen section interpretation of benign and malignant central nervous system lesions. … This would be an excellent addition to any surgical pathologist’s library. The book is succinct and covers practical material for anyone who provides intraoperative consultations for neuropathology specimens. … an excellent quick reference and is unique in its focus on frozen section interpretation.” (Roger Dietz, Doody’s Review Service, February, 2011)

“The volume under review is dedicated to CNS frozen section intraoperative diagnosis. … It may be lightweight in size but not in content. This diminutive monograph contains a wealth of well-organized, accessible information, punctuated by copious colour micrographs and helpful tables. The authors have a wealth of experience to communicate and the comprehensive, knowledgably expressed content means this little textbook has every right to sit between those weightier tomes.” (Timothy Dawson, Neuropathology and Applied Neurobiology, Vol. 37, 2011)

• Dept. Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, USA

  Richard A. Prayson

• , Dept. Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, USA

  Karl M. Napekoski

Richard A. Prayson, MD, is at the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH. Karl M. Napekoski, MD, is at the Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH.

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