Polyomaviruses and Human Diseases

1. Front Matter

   Pages i-xxiv

   PDF

2. Polyomaviruses and Human Diseases

   • Nasimul Ahsan, Keerti V. Shah

   Pages 1-18

3. Discovery and Epidemiology of the Human Polyomaviruses BK Virus (BKV) and JC Virus (JCV)

   • Wendy A. Knowles

   Pages 19-45

4. Phylogenomics and Molecular Evolution of Polyomaviruses

   • Keith A. Crandall, Marcos Prérez-Losada, Ryan G. Christensen, David A. McClellan, Raphael P. Viscidi

   Pages 46-59

5. Virus Receptors and Tropism

   • Aarthi Ashok, Walter J. Atwood

   Pages 60-72

6. Serological Cross Reactivity between Polyomavirus Capsids

   • Raphael P. Viscidi, Barbara Clayman

   Pages 73-84

7. Molecular Genetics of the BK Virus

   • Christopher L. Cubitt

   Pages 85-95

8. Serological Diagnosis of Human Polyomavirus Infection

   • Annika Lundstig, Joakim Dillner

   Pages 96-101

9. Human Polyomavirus JC and BK Persistent Infection

   • Kristina Doerries

   Pages 102-116

10. Immunity and Autoimmunity Induced by Polyomaviruses

    • Ole Petter Rekvig, Signy Bendiksen, Ugo Moens

    Pages 117-147

11. The Pathobiology of Polyomavirus Infection in Man

    • Parmjeet Randhawa, Abhay Vats, Ron Shapiro

    Pages 148-159

12. Polyomavirus-Associated Nephropathy in Renal Transplantation

    • Hans H. Hirsch, Cinthia B. Drachenberg, Juerg Steiger, Emilio Ramos

    Pages 160-173

13. BK Virus and Immunosuppressive Agents

    • Irfan Agha, Daniel C. Brennan

    Pages 174-184

14. BK Virus Infection after Non-Renal Transplantation

    • Martha Pavlakis, Abdolreza Haririan, David K. Klassen

    Pages 185-189

15. Latent and Productive Polyomavirus Infections of Renal Allografts

    • Volker Nickeleit, Harsharan K. Singh, Michael J. Mihatsch

    Pages 190-200

16. Urine Cytology Findings of Polyomavirus Infections

    • Harsharan K. Singh, Lukas Bubendorf, Michael J. Mihatsch, Cinthia B. Drachenberg, Volker Nickeleit

    Pages 201-212

17. Diagnosis and Treatment of BK Virus-Associated Transplant Nephropathy

    • Abhay Vats, Parmjeet Randhawa, Ron Shapiro

    Pages 213-227

18. Pharmacotherapeutic Options for the Management of Human Polyomaviruses

    • Julie Roskopf, Jennifer Trofe, Robert J. Stratta, Nasimul Ahsan

    Pages 228-254

19. Leflunomide in Solid Organ Transplantation and Polyoma Virus Infection

    • Michelle A. Josephson, Basit Javaid, Pradeep V. Kadambi, Shane M. Meehan, James W. Williams

    Pages 255-265

20. JC Virus Can Infect Human Immune and Nervous System Progenitor Cells

    • Jean Hou, Pankaj Seth, Eugene O. Major

    Pages 266-273

Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica­ tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph­ ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before.

• Nervous System
• autoimmunity
• histopathology
• infection
• infections
• transplantation
• virus
• infectious diseases

• Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, USA

  Nasimul Ahsan

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