Overview
- Editors:
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Danny R. Welch
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Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, USA
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Table of contents (14 chapters)
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Front Matter
Pages i-xiii
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- Barbara A. Yoshida, Zita Dubauskas, Mitchell H. Sokoloff, Danny R. Welch, Carrie W. Rinker-Schaeffer
Pages 1-33
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- Garth L. Nicolson, Akihiro Nawa, Yasushi Toh, Shigeki Taniguchi, Katsuhiko Nishimori
Pages 51-63
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- Yasuharu Onishi, Arayo Haga, Avraham Raz
Pages 109-122
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- Patricia S. Steeg, Taoufik Ouatas, Michael Mair, Susan E. Clare, Melanie T. Hartsough
Pages 123-143
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- Dawn A. Kirschmann, Mary J.C. Hendrix
Pages 169-189
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- Gary G. Meadows, Xiaokang Ge, Hui Zhang, Daniel R. Oros, Ya-Min Fu
Pages 191-208
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- Rajeev S. Samant, Lalita R. Shevde, Danny R Welch
Pages 209-217
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- John F. Harms, Danny R. Welch
Pages 219-229
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- Ann F. Chambers, Alan B. Tuck
Pages 231-246
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- Stephen G. Zimmer, Jeremy R. Graff
Pages 247-264
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Back Matter
Pages 267-270
About this book
Being diagnosed with cancer is devastating. But when the cancer cells have to spread to form secondary colonies, the prognosis for the patient is worse. If meaningful improvements in survival are to occur, then control of metastasis will be a foundation. Relatively little is known about the control of the metastatic process at the molecular level. This volume begins to explore our current knowledge regarding the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this. Nonetheless, we write these summaries of our work as an early effort toward that end. I am grateful to all of the authors who have contributed generously of their time and energies to make this volume a reality. To metastasize, neoplastic cells dissociate from the primary tumor, enter a circulatory compartment (typically lymphatics or blood vasculature), survive transport, arrest, exit the circulation and finally proliferate at a discontinuous site in response to local growth factors. Unless cells accomplish every step of the metastatic cascade, metastases cannot develop. The process is highly inefficient, i. e. ,
Editors and Affiliations
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Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, USA
Danny R. Welch
