RNA Towards Medicine

ISBN: 978-3-540-27261-8 (Print) 978-3-540-27262-5 (Online)

Table of contents (23 chapters)

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  1. Front Matter

    Pages I-XI

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    Chapter

    Pages 1-8

    Why RNA and DNA Have Different Structures

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    Chapter

    Pages 9-43

    Regulatory RNAs as Mediators of Virulence Gene Expression in Bacteria

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    Chapter

    Pages 45-72

    Regulatory RNAs in Mammals

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    Chapter

    Pages 73-96

    Aminoglycoside Interactions with RNAs and Nucleases

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    Chapter

    Pages 97-104

    High-Throughput RNA Interference in Functional Genomics

  7. Chapter

    Pages 105-116

    Antiviral Applications of RNAi

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    Chapter

    Pages 117-150

    RNA Interference: Its Use as Antiviral Therapy

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    Chapter

    Pages 151-171

    Gene Silencing of Virus Replication by RNA Interference

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    Chapter

    Pages 173-196

    Progress in the Development of Nucleic Acid Therapeutics

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    Chapter

    Pages 197-221

    Screening and Determination of Gene Function Using Randomized Ribozyme and siRNA Libraries

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    Chapter

    Pages 223-242

    Ribozymes and siRNAs: From Structure to Preclinical Applications

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    Chapter

    Pages 243-259

    Strategies to Identify Potential Therapeutic Target Sites in RNA

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    Chapter

    Pages 261-287

    Oligonucleotide-Based Antiviral Strategies

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    Chapter

    Pages 289-303

    Gene-Expressed RNA as a Therapeutic: Issues to Consider, Using Ribozymes and Small Hairpin RNA as Specific Examples

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    Chapter

    Pages 305-326

    RNA Aptamers: From Basic Science Towards Therapy

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    Chapter

    Pages 327-340

    RNA Aptamers Directed Against Oligosaccharides

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    Chapter

    Pages 341-357

    Aptamer-Based Biosensors: Biomedical Applications

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    Chapter

    Pages 359-373

    Application of Aptamers in Therapeutics and for Small-Molecule Detection

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    Chapter

    Pages 375-393

    RNA Aptamers as Potential Pharmaceuticals Against Infections with African Trypanosomes

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    Chapter

    Pages 395-403

    RNA Targeting Using Peptide Nucleic Acid

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