Inhibitors of Protein Kinases and Protein Phosphates

ISBN: 978-3-540-21242-3 (Print) 978-3-540-26670-9 (Online)

Table of contents (16 chapters)

  1. No Access

    Book Chapter

    Pages 1-7

    Protein Kinase Inhibitors for the Treatment of Disease: The Promise and the Problems

  2. General Aspects of PKs Inhibition

    1. No Access

      Book Chapter

      Pages 11-44

      New Design Strategies for Ligands That Target Protein Kinase-Mediated Protein-Protein Interactions

  3. Pharmacological Potential and Inhibitors of Individual Classes of Protein Kinases

    1. No Access

      Book Chapter

      Pages 47-64

      The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3

    2. No Access

      Book Chapter

      Pages 65-83

      Pharmacological Potential of p38 MAPK Inhibitors

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      Book Chapter

      Pages 85-124

      Inhibitors of PKA and Related Protein Kinases

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      Book Chapter

      Pages 125-155

      Inhibitors of Protein Kinase CK2: Structural Aspects

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      Book Chapter

      Pages 157-188

      Aminoglycoside Kinases and Antibiotic Resistance

  4. Pharmacological Potential and Inhibitors of Individual Classes of Protein Phosphatases

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      Book Chapter

      Pages 191-214

      Protein Tyrosine Phosphatases as Therapeutic Targets

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      Book Chapter

      Pages 215-262

      Structure-Based Design of Protein Tyrosine Phosphatase Inhibitors

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      Book Chapter

      Pages 263-293

      Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Target

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      Book Chapter

      Pages 295-317

      Serine/Threonine Protein Phosphatase Inhibitors with Antitumor Activity

  5. Inhibitors in Clinical Use or Advanced Clinical Trials

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      Book Chapter

      Pages 321-359

      Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimus

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      Book Chapter

      Pages 361-389

      Targeted Therapy with Imatinib: An Exception or a Rule?

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      Book Chapter

      Pages 391-410

      Clinical Aspects of Imatinib Therapy

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      Book Chapter

      Pages 411-432

      Isoquinolinesulfonamide: A Specific Inhibitor of Rho-Kinase and the Clinical Aspect of Anti-Rho-Kinase Therapy

    5. No Access

      Book Chapter

      Pages 433-450

      Discovery and Development of Iressa: The First in a New Class of Drugs Targeted at the Epidermal Growth Factor Receptor Tyrosine Kinase