St. John's Wort and its Active Principles in Depression and Anxiety


ISBN: 978-3-7643-6160-0 (Print) 978-3-7643-7338-2 (Online)

Table of contents (13 chapters)

  1. Front Matter

    Pages I-VIII

  2. Chapter

    Pages 1-4

    Introduction and historical overview

  3. Chapter

    Pages 5-20


  4. Chapter

    Pages 21-29

    St. John’s Wort and its active principles in depression and anxiety — A critical analysis of receptor binding studies

  5. Chapter

    Pages 31-46

    Effects on transmitter uptake and their cellular and molecular basis

  6. Chapter

    Pages 47-58

    Modulation of neurotransmitter release and metabolism

  7. Chapter

    Pages 59-71

    Efficacy in behavioural models of antidepressant activity

  8. Chapter

    Pages 73-84

    Comparative preclinical antidepressant activity of isolated constituents

  9. Chapter

    Pages 85-97

    Hyperforin and efficacy in animal models for anxiety and cognition

  10. Chapter

    Pages 99-121

    Pharmacokinetics and biopharmaceuticals

  11. Chapter

    Pages 123-131

    Clinical efficacy in depression

  12. Chapter

    Pages 133-143

    Clinical efficacy of St. John’s Wort in psychiatric disorders other than depression

  13. Chapter

    Pages 145-160

    Side effects and drug interactions

  14. Chapter

    Pages 161-181

    Endocrinology of St. John’s Wort extract

  15. Back Matter

    Pages 183-188