Volume 4 2006

Protein Misfolding, Aggregation, and Conformational Diseases

Part A: Protein Aggregation and Conformational Diseases

Editors:

ISBN: 978-0-387-25918-5 (Print) 978-0-387-25919-2 (Online)

Table of contents (19 chapters)

  1. Structural and Conformational Prerequisites of Amyloidogenesis

    1. No Access

      Book Chapter

      Pages 1-20

      Structural and Conformational Prerequisites of Amyloidogenesis

  2. The Generic Nature of Protein Folding and Misfolding

    1. No Access

      Book Chapter

      Pages 21-41

      The Generic Nature of Protein Folding and Misfolding

  3. Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation

    1. No Access

      Book Chapter

      Pages 43-59

      Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation

  4. Cytotoxic Intermediates in the Fibrillation Pathway: Aβ Oligomers in Alzheimer’s Disease as a Case Study

    1. No Access

      Book Chapter

      Pages 60-81

      Cytotoxic Intermediates in the Fibrillation Pathway: Aβ Oligomers in Alzheimer’s Disease as a Case Study

  5. Glycosaminoglycans, Proteoglycans, and Conformational Disorders

    1. No Access

      Book Chapter

      Pages 83-100

      Glycosaminoglycans, Proteoglycans, and Conformational Disorders

  6. Apolipoproteins in Different Amyloidoses

    1. No Access

      Book Chapter

      Pages 101-122

      Apolipoproteins in Different Amyloidoses

  7. Oxidative Stress and Protein Deposition Diseases

    1. No Access

      Book Chapter

      Pages 123-133

      Oxidative Stress and Protein Deposition Diseases

  8. Chaperone and Conformational Disorders

    1. Front Matter

      Pages 135-135

    2. No Access

      Book Chapter

      Pages 137-164

      Chaperone Suppression of Aggregated Protein Toxicity

    3. No Access

      Book Chapter

      Pages 165-174

      Mechanisms of Active Solubilization of Stable Protein Aggregates by Molecular Chaperones

  9. The Aggresome: Proteasomes, Inclusion Bodies, and Protein Aggregation

    1. No Access

      Book Chapter

      Pages 175-222

      The Aggresome: Proteasomes, Inclusion Bodies, and Protein Aggregation

  10. Protein Aggregation, Ion Channel Formation, and Membrane Damage

    1. No Access

      Book Chapter

      Pages 223-236

      Protein Aggregation, Ion Channel Formation, and Membrane Damage

  11. Visualization of Protein Deposits In Vivo

    1. Front Matter

      Pages 237-237

    2. No Access

      Book Chapter

      Pages 239-276

      Congo Red Staining of Amyloid: Improvements and Practical Guide for a More Precise Diagnosis of Amyloid and the Different Amyloidoses

    3. No Access

      Book Chapter

      Pages 277-283

      Immunohistological Study of Experimental Murine AA Amyloidosis

  12. Visualization of Protein Deposits In Vitro

    1. Front Matter

      Pages 285-285

    2. No Access

      Book Chapter

      Pages 287-302

      Reporters of Amyloid Structure

    3. No Access

      Book Chapter

      Pages 303-313

      Three-Dimensional Structural Analysis of Amyloid Fibrils by Electron Microscopy

    4. No Access

      Book Chapter

      Pages 315-334

      Atomic Force Microscopy

    5. No Access

      Book Chapter

      Pages 335-343

      Direct Observation of Amyloid Fibril Growth Monitored by Total Internal Reflection Fluorescence Microscopy

  13. Animal and Cell Models of Human Neurodegenerative Disorders

    1. Front Matter

      Pages 345-345

    2. No Access

      Book Chapter

      Pages 347-369

      Drosophila and C. elegans Models of Human Age-Associated Neurodegenerative Diseases

    3. No Access

      Book Chapter

      Pages 371-408

      Genetically Engineered Mouse Models of Neurodegenerative Disorders