Cancer Gene Therapy

Past Achievements and Future Challenges

Editors:

ISBN: 978-0-306-46191-0 (Print) 978-0-306-46817-9 (Online)

Table of contents (41 chapters)

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  1. The Clinical Problem

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      Pages 3-10

      Management Problems in Oncology

  2. Vectors

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      Pages 13-22

      Adenoviral Vectors

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      Pages 23-35

      Retrovirus Vectors

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      Pages 37-46

      Targetable Gene Delivery Vectors

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      Pages 47-56

      Human α-fetoprotein Transcriptional Regulatory Sequences

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      Pages 57-63

      Tumor-Targeted Salmonella

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      Pages 65-71

      Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells

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      Pages 73-82

      Polyoma and Papilloma Virus Vectors For Cancer Gene Therapy

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      Pages 83-93

      Cochleates

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      Pages 95-111

      The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer

  3. Cell Cycle Control

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      Pages 115-126

      Adhesion Molecules in Cancer Biology

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      Pages 127-140

      Cell Cycle Control

  4. Apoptosis

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      Pages 143-151

      Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death

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      Pages 153-161

      Apoptin®

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      Book Chapter

      Pages 163-170

      Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors

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      Book Chapter

      Pages 171-180

      Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/neu-overexpressing Breast and Ovarian Cancer

  5. Tumout Suppressor Genes

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      Pages 183-192

      Pre-clinical Studies with Tumor Suppressor Genes

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      Pages 193-205

      Gene Therapy for Liver Tumours

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      Pages 207-214

      Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer

  6. Other Systems

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      Book Chapter

      Pages 217-227

      Eliciting Hyperacute Rejection as a Tumor Killing Strategy

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