Volume 3 2005

Proteomics and Protein-Protein Interactions

Biology, Chemistry, Bioinformatics, and Drug Design

Editors:

ISBN: 978-0-387-24531-7 (Print) 978-0-387-24532-4 (Online)

Table of contents (13 chapters)

  1. No Access

    Book Chapter

    Pages 1-18

    Introduction: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design

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    Book Chapter

    Pages 19-31

    Yeast Two-Hybrid Protein-Protein Interaction Networks

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    Book Chapter

    Pages 33-48

    The Use of Mass Spectrometry in Studying Protein-Protein Interaction

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    Book Chapter

    Pages 49-87

    Molecular Recognition in the Immune System

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    Book Chapter

    Pages 89-114

    Computational Methods for Predicting Protein-Protein Interactions

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    Book Chapter

    Pages 115-146

    Protein-Protein Docking Methods

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    Book Chapter

    Pages 147-163

    Thermochemistry of Binary and Ternary Protein Interactions Measured by Titration Calorimetry: Complex Formation of CD4, HIV gp120, and Anti-gp120

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    Book Chapter

    Pages 165-184

    Protein-Protein Recognition in Phosphotyrosine-Mediated Intracellular Signaling

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    Book Chapter

    Pages 185-201

    Competitive Binding of Proline-Rich Sequences by SH3, WW, and Other Functionally Related Protein Domains

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    Book Chapter

    Pages 203-218

    The Structure and Molecular Interactions of the Bromodomain

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    Book Chapter

    Pages 219-253

    SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60src (Src)

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    Book Chapter

    Pages 255-289

    Disrupting Protein-Protein Interaction: Therapeutic Tools Against Brain Damage

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    Book Chapter

    Pages 291-307

    A Thermodynamic Guide to Affinity Optimization of Drug Candidates