Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3

Editors:

ISBN: 978-1-4020-7804-0 (Print) 978-0-306-48523-7 (Online)

Table of contents (15 chapters)

  1. Mechanism-Based PK/PD

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-32

      Physiological Modeling of the Small Intestine in Drug Absorption

    3. No Access

      Book Chapter

      Pages 33-47

      Intracellular Metabolism of Lamivudine

    4. No Access

      Book Chapter

      Pages 49-65

      Mechanism-Based Pharmacodynamic Modeling for Prediction of Exposure Response

    5. No Access

      Book Chapter

      Pages 67-83

      Mechanism-Based PK/PD Modeling of Digoxin: Role of Receptor Heterogeneity and Postrecepotor Events

    6. No Access

      Book Chapter

      Pages 85-103

      Pharmacodynamics and Pharmacogenomics of Corticosteroids: Microarray Studies

    7. No Access

      Book Chapter

      Pages 105-131

      Bayesian Inference in Physiologically-based Pharmacokinetic Modeling: Application to Aniticancer Drug Development

  2. Pharmacometrics

    1. Front Matter

      Pages 133-133

    2. No Access

      Book Chapter

      Pages 135-163

      Monte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/Pharmacodynamic Data

    3. No Access

      Book Chapter

      Pages 165-177

      Applications of Markov Chain Monte Carlo Methods to Inverse Problems in PK/PD

    4. No Access

      Book Chapter

      Pages 179-196

      Regenerative Markov Chain Monte Carlo Methods for Pharmacokinetic/Pharmacodynamic Estimation

    5. No Access

      Book Chapter

      Pages 197-207

      Vizstruct: A Multidimensional Visualization Algorithm for Gene Expression

  3. Pharmacotherapy

    1. Front Matter

      Pages 209-209

    2. No Access

      Book Chapter

      Pages 211-220

      Modeling and Simulation of Effects of Adherence, Pharmacokinetic, and Pharmacodynamic Characteristics in Development of Resistance to HIV Regimens in Treatment-Naive Patients

    3. No Access

      Book Chapter

      Pages 221-237

      Mechanistic PK/PD Modeling of Antiretroviral Therapies in AIDS Clinical Trials

    4. No Access

      Book Chapter

      Pages 239-253

      Dose Individualization for High-dose anti-cancer Chemotherapy

    5. No Access

      Book Chapter

      Pages 255-274

      Toward Model-Based Chemotherapy Treatment Design

    6. No Access

      Book Chapter

      Pages 275-293

      Control of Uncertain Pharmacodynamic Systems