2013

Evolution-adjusted Tumor Pathophysiology:

The Novel Language of Tumor Biology

Editors:

ISBN: 978-94-007-6865-9 (Print) 978-94-007-6866-6 (Online)

Table of contents (23 chapters)

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  1. Front Matter

    Pages i-x

  2. Introduction

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-9

      Communication—Evolution—Pathophysiology: An Endogenous Conjunction—Instead of an Introduction

  3. Combined Modularized Therapies for Metastatic Tumors: Pointing to Central Problems of Communication Among ‘Systems Participators’ in Tumors

    1. Front Matter

      Pages 11-11

    2. No Access

      Book Chapter

      Pages 13-28

      Applied Systems Biology for the Control of Metastatic Cancer: Therapeutic Top-Down Strategy for Targeting the Tumors’ Normativity

    3. No Access

      Book Chapter

      Pages 29-33

      Targeting the Proangiogenic Network in Angiosarcomas: Biomodulatory Therapy

    4. No Access

      Book Chapter

      Pages 35-45

      Long-Term Results of Combined Modularized, Immune-Modulatory, Angiostatic, and Antiinflammatory Therapy in Systemically Pre-Treated Multi-Systems Langerhans Cell Histiocytosis

    5. No Access

      Book Chapter

      Pages 47-66

      Redirecting and Modulating Rationalizations of Tumor-Immanent Normative Functions in Castration-Resistant Prostate Cancer

  4. Social Engineering: Biomodulation, Either Endogenously Initiated or by Implementation of Non-normative Boundary Conditions

    1. Front Matter

      Pages 67-67

    2. No Access

      Book Chapter

      Pages 69-90

      Non-Hierarchically Organized Operations in Malignancies: Stromal Dysfunction Induces and Maintains Hematopoietic Malignancies

    3. No Access

      Book Chapter

      Pages 91-100

      Biomodulatory Therapy Approaches in Renal Clear Cell Carcinoma: A Perspective

    4. No Access

      Book Chapter

      Pages 101-141

      Proteome Analysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progression and Interfering with Tumor-Stroma Interaction

  5. The Tumors’ Normativity: Reconstructing and Operationalizing Starting Points for an Evolution Theory

    1. Front Matter

      Pages 143-143

    2. No Access

      Book Chapter

      Pages 145-154

      The Philosophical Quest of a Cancer Cell: Redefining Existentialism

    3. No Access

      Book Chapter

      Pages 155-167

      The Tumor’s Normativity: Normative Structures, Action Norms and Decision Maxims as Therapeutic Targets for Tumor Therapy

    4. No Access

      Book Chapter

      Pages 169-187

      Criticizable Claims for the Validity of Communication Acts in Biological Systems: Therapeutic Implications in Cancer

  6. Evolution Theory

    1. Front Matter

      Pages 189-189

    2. No Access

      Book Chapter

      Pages 191-238

      Evolution Theory: Its Practical Relevance for Understanding Tumor Development and Specifying Tumor Therapy

    3. No Access

      Book Chapter

      Pages 239-247

      Modularity, Subjectivity, Intersubjectivity and Normativity: Clinically Applicable Operative Benchmarks

    4. No Access

      Book Chapter

      Pages 249-257

      Turning Upside Down the Mode of Science to Emphasize and Harness the Impact of Environmental Communication

  7. From Genome- or Organ-centric to Rationalization-centric Systematization of Tumors

    1. Front Matter

      Pages 259-259

    2. No Access

      Book Chapter

      Pages 261-288

      Purposive-Rational Tumor Therapy: Exploiting the Tumor’s ‘Living World’ for Diversifying, Specifying and Personalizing Tumor Therapy

    3. No Access

      Book Chapter

      Pages 289-299

      Including Rationalizations of Tumor-Associated Normative Notions in Pathophysiologic Considerations: Communication-Theoretical Implications

  8. Reconstruction of Tumor-Immanent Normative Functions, Structures and Decision Maxims (Hubs)

    1. Front Matter

      Pages 301-301

    2. No Access

      Book Chapter

      Pages 303-321

      Bridging a Diagnostic and Therapeutic Gap: Selecting, Assessing and Categorizing, Tumor-associated Normative Notions

    3. No Access

      Book Chapter

      Pages 323-341

      Personalizing Tumor Pathophysiology by Diagnosing Developmental Problems in Tumors with Imaging Techniques

    4. No Access

      Book Chapter

      Pages 343-361

      Biologic Memory: Induction by Metronomically Administered Combined Modularized Therapy

  9. The Tool of Rationalizations Constituting Tumor-Associated Normative Notions: The Non-Genomic Counterpart of the Tumor Genome and Therefore, an Important Therapeutic Target for Diversifying Palliative Care

    1. Front Matter

      Pages 363-363

    2. No Access

      Book Chapter

      Pages 365-395

      Diversifying and Specifying Palliative Care for Patients with Metastatic Cancer by Therapeutic Implementation of Non-Normative Boundary Conditions

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