Tumor Dormancy, Quiescence, and Senescence, Volume 1

Aging, Cancer, and Noncancer Pathologies

Editors:

ISBN: 978-94-007-5957-2 (Print) 978-94-007-5958-9 (Online)

Table of contents (26 chapters)

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  1. Front Matter

    Pages i-xxiv

  2. Tumor Dormancy

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-5

      Dormancy, Quiescence, and Cellular Senescence

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      Book Chapter

      Pages 7-21

      Is Tumor Dormancy Clinically Relevant?

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      Book Chapter

      Pages 23-33

      Microenvironmental Influence on Breast Cancer Dormancy and Metastasis

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      Book Chapter

      Pages 35-50

      Determination of Breast Cancer Dormancy: Analysis of Circulating Free DNA Using SNP 6.0 Arrays

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      Book Chapter

      Pages 51-62

      Clonogenicity of Cultured Prostate Cancer Cells Is Controlled by Dormancy: Significance and Comparison with Cell Culture Models of Breast Cancer Cell Dormancy

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      Book Chapter

      Pages 63-78

      Dormancy and Metastasis of Melanoma Cells to Lymph Nodes, Lung and Liver

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      Book Chapter

      Pages 79-83

      Late Recurrence Is a Sign of Melanoma Dormancy: Need of Life-Long Follow-Up of Melanoma Patients

  3. Quiescence

    1. Front Matter

      Pages 85-85

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      Book Chapter

      Pages 87-105

      Hematopoietic Stem Cell Quiescence and Long Term Maintenance: Role of SCL/TAL1

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      Book Chapter

      Pages 107-116

      Regulation of Muscle Stem Cell Quiescent and Undifferentiated State: Roles of Hesr1 and Hesr3 Genes

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      Book Chapter

      Pages 117-126

      The Kinase MIRK/DYRK1B Mediates a Reversible Quiescent State in a Subset of Ovarian, Pancreatic and Colon Cancers

  4. Cellular Senescence

    1. Front Matter

      Pages 127-127

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      Book Chapter

      Pages 129-139

      Stress-Induced Senescence: Molecular Pathways

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      Book Chapter

      Pages 141-151

      Accumulation of Reactive Oxygen Species and Induction of Premature Senescence: Role of DDB2

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      Book Chapter

      Pages 153-167

      p21 Mediates Senescence by a Mechanism Involving Accumulation of Reactive Oxygen Species

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      Book Chapter

      Pages 169-180

      Role of MicroRNAs and ZEB1 Downmodulation in Oxidative Stress-Induced Apoptosis and Senescence

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      Book Chapter

      Pages 181-194

      Hypoxic Response in Senescent Brain Is Impaired: Possible Contribution to Neurodegeneration

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      Book Chapter

      Pages 195-205

      Enhancing Reprogramming to Pluripotency by Controlling Senescence

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      Book Chapter

      Pages 207-214

      Histone Deacetylase Inhibitor Induces Replicative Senescence of Mesenchymal Stem Cells

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      Book Chapter

      Pages 215-226

      Senescence Arrest of Endopolyploid Cells Renders Senescence into One Mechanism for Positive Tumorigenesis

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      Book Chapter

      Pages 227-235

      The Two Faces of Senescence-Associated Epigenetic Alterations: Tumor Suppressors and Oncogenic Drivers

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      Book Chapter

      Pages 237-248

      Chemotherapy- and Radiation-Induced Accelerated Senescence: Implications for Treatment Response, Tumor Progression and Cancer Survivorship

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