Book 2012

Systems Biology in Cancer Research and Drug Discovery


ISBN: 978-94-007-4818-7 (Print) 978-94-007-4819-4 (Online)

Table of contents (18 chapters)

  1. Front Matter

    Pages i-xii

  2. Systems Biology in Cancer

    1. Front Matter

      Pages 1-1

    2. Chapter

      Pages 3-37

      Systems Biology Approach to Metabolomics in Cancer Studies

    3. Chapter

      Pages 39-67

      System Biology Approach to Study Cancer Related Pathways

    4. Chapter

      Pages 69-81

      Modeling Oncogenic Signaling Networks from Gene Expression Dynamics

    5. Chapter

      Pages 83-111

      An Integrated Systems Approach to the Study of Pancreatic Cancer

    6. Chapter

      Pages 113-134

      Protein Microarray: An Ideal Platform for Systems Biology

    7. Chapter

      Pages 135-164

      Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance

  3. Systems Approaches to Understand Cancer Progression

    1. Front Matter

      Pages 165-165

    2. Chapter

      Pages 167-195

      Understanding Cancer Progression Using Protein Interaction Networks

    3. Chapter

      Pages 197-227

      Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach

    4. Chapter

      Pages 229-244

      Applications of Network Bioinformatics to Cancer Angiogenesis

  4. Systems and Network Biology in Decoding miRNA Complexity

    1. Front Matter

      Pages 245-245

    2. Chapter

      Pages 247-266

      Human MicroRNA Targetome Indicates a Specialized Role of MicroRNAs in Regulation of Oncogenesis

    3. Chapter

      Pages 267-288

      Novel and Alternative Bioinformatics Approaches to Understand miRNA-mRNA Interactome in Cancer Research

    4. Chapter

      Pages 289-306

      Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA-Target Dysregulated Network

  5. Network Modeling in Cancer Drug Discovery and Clinical Trials

    1. Front Matter

      Pages 307-307

    2. Chapter

      Pages 309-323

      Development and Clinical Implementation of Reverse Phase Protein Microarrays for Protein Network Activation Mapping: Personalized Cancer Therapy

    3. Chapter

      Pages 325-337

      The Principle of Rational Design of Drug Combination and Personalized Therapy Based on Network Pharmacology

    4. Chapter

      Pages 339-362

      Relevance of Network Hierarchy in Cancer Drug-Target Selection

    5. Chapter

      Pages 363-392

      Computational Infrastructures for Large-Scale Data Access and Analysis in Post-Genomic Clinical Trials

    6. Chapter

      Pages 393-418

      Network Pharmacology: An Emerging Area in Anti-Cancer Drug Discovery

  6. Chapter

    Pages E1-E2

    Erratum: Chapter 17 Network Pharmacology: An Emerging Area in Anti-Cancer Drug Discovery

  7. Back Matter

    Pages 419-423