2012

Statistics Applied to Clinical Studies

Authors:

ISBN: 978-94-007-2862-2 (Print) 978-94-007-2863-9 (Online)

Table of contents (67 chapters)

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  1. Front Matter

    Pages i-xxxv

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    Pages 1-14

    Hypotheses, Data, Stratification

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    Pages 15-39

    The Analysis of Efficacy Data

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    Pages 41-60

    The Analysis of Safety Data

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    Pages 61-68

    Log Likelihood Ratio Tests for Safety Data Analysis

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    Pages 69-75

    Equivalence Testing

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    Pages 77-93

    Statistical Power and Sample Size

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    Pages 95-101

    Interim Analyses

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    Pages 103-108

    Controlling the Risk of False Positive Clinical Trials

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    Pages 109-117

    Multiple Statistical Inferences

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    Pages 119-131

    The Interpretation of the p-Values

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    Pages 133-138

    Research Data Closer to Expectation than Compatible with Random Sampling

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    Pages 139-147

    Statistical Tables for Testing Data Closer to Expectation than Compatible with Random Sampling

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    Pages 149-159

    Data Dispersion Issues

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    Pages 161-176

    Linear Regression, Basic Approach

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    Pages 177-186

    Linear Regression for Assessing Precision, Confounding, Interaction, Basic Approach

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    Pages 187-197

    Curvilinear Regression

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    Pages 199-218

    Logistic and Cox Regression, Markov Models, Laplace Transformations

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    Pages 219-225

    Regression Modeling for Improved Precision

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    Pages 227-231

    Post-hoc Analyses in Clinical Trials, A Case for Logistic Regression Analysis

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    Book Chapter

    Pages 233-242

    Multistage Regression

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