Systems Biology in Biotech & Pharma

A Changing Paradigm


ISBN: 978-94-007-2848-6 (Print) 978-94-007-2849-3 (Online)

Table of contents (11 chapters)

  1. Front Matter

    Pages i-xviii

  2. Chapter

    Pages 1-10

    Introduction: Discovery and Development—New Facet of Industry, New Tools and Lead Optimization

  3. Chapter

    Pages 11-23

    Discovery: Use of Systems Biology for Identifying Targets

  4. Chapter

    Pages 25-38

    Integrative Systems Biology I—Biochemistry: Phase I Lead Discovery and Molecular Interactions

  5. Chapter

    Pages 39-49

    Integrative Systems Biology II—Molecular Biology: Phase 2 Lead Discovery and In Silico Screening

  6. Chapter

    Pages 51-67

    Discovery: Computational Systems Biology (CSB) in Health and Disease I

  7. Chapter

    Pages 69-76

    Development: In Vivo Pharmacology—Systems Biology in Health and Disease II

  8. Chapter

    Pages 77-85

    Development: Pharmacokinetics—Systems Biology in Health and Disease III

  9. Chapter

    Pages 87-102

    Development: Multiscale CSB—Simulation Tools

  10. Chapter

    Pages 103-107

    Development: Drug Formulation and Delivery

  11. Chapter

    Pages 109-113

    Development: Preclinical Model Based Drug Development

  12. Chapter

    Pages 115-127

    Systems Biology: Impact on Pharma and Biotech