2012

Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases

Editors:

ISBN: 978-94-007-2773-1 (Print) 978-94-007-2774-8 (Online)

Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii

  2. No Access

    Book Chapter

    Pages 1-36

    Overview of Fibrillar and Oligomeric Assemblies of Amyloidogenic Proteins

  3. No Access

    Book Chapter

    Pages 37-60

    Pathologic Lesions in Alzheimer Disease and Other Neurodegenerative Diseases—Cellular and Molecular Components

  4. No Access

    Book Chapter

    Pages 61-102

    Preparation and Structural Characterization of Pre-fibrillar Assemblies of Amyloidogenic Proteins

  5. No Access

    Book Chapter

    Pages 103-133

    Biological Targeting and Activity of Pre-fibrillar Aβ Assemblies

  6. No Access

    Book Chapter

    Pages 135-188

    The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s Disease

  7. No Access

    Book Chapter

    Pages 189-216

    Oligomers of α-Synuclein in the Pathogenesis of Parkinson’s Disease

  8. No Access

    Book Chapter

    Pages 217-255

    Cytotoxic Mechanisms of Islet Amyloid Polypeptide in the Pathogenesis of Type-2 Diabetes Mellitus (T2DM)

  9. No Access

    Book Chapter

    Pages 257-288

    Protein Misfolding and Toxicity in Amyotrophic Lateral Sclerosis

  10. No Access

    Book Chapter

    Pages 289-317

    Structural Studies of Prion Proteins and Prions

  11. No Access

    Book Chapter

    Pages 319-335

    Role of Prion Protein Oligomers in the Pathogenesis of Transmissible Spongiform Encephalopathies

  12. No Access

    Book Chapter

    Pages 337-375

    When More Is Not Better: Expanded Polyglutamine Domains in Neurodegenerative Disease

  13. No Access

    Book Chapter

    Pages 377-405

    Protein Misfolding and Toxicity in Dialysis-Related Amyloidosis

  14. No Access

    Book Chapter

    Pages 407-432

    Transthyretin Aggregation and Toxicity

  15. No Access

    Book Chapter

    Pages 433-560

    Strategies for Inhibiting Protein Aggregation: Therapeutic Approaches to Protein-Aggregation Diseases

  16. Back Matter

    Pages 561-565