From Molecular to Modular Tumor Therapy

Tumors are Reconstructible Communicatively Evolving Systems

Editors:

ISBN: 978-90-481-9530-5 (Print) 978-90-481-9531-2 (Online)

Table of contents (27 chapters)

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  1. Front Matter

    Pages i-viii

  2. Therapy-Derived Systems Biology: A Pragmatic Communication Theory

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-7

      Bridging Theory and Therapeutic Practice: From Generalized Disease Models to Particular Patients

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      Book Chapter

      Pages 9-28

      Tumor Systems Need to be Rendered Usable for a New Action-Theoretical Abstraction: The Starting Point for Novel Therapeutic Options

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      Book Chapter

      Pages 29-47

      Principles of Modular Tumor Therapy

  3. Tumors Share Common Processes During Tumor Evolution: Communicative Aspects of a Situation’s Interpretation for Creating Systems-Directed Therapies

    1. Front Matter

      Pages 49-49

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      Book Chapter

      Pages 51-74

      Cancer and Coagulation; Focusing on Tissue Factor and Heparanase

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      Book Chapter

      Pages 75-96

      The Role of Mesenchymal Cells in Cancer: Contribution to Tumor Stroma and Tumorigenic Capacity

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      Book Chapter

      Pages 97-110

      Shaping Tumor Associated Macrophages: The Role of NF-κB

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      Book Chapter

      Pages 111-132

      The Metabolic Achilles Heel: Tumor Cell Metabolism as Therapeutic Target

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      Book Chapter

      Pages 133-157

      Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients?

  4. Systems-Relevant Molecular and Cellular Targets: Implementation of Modular ‘Knowledge’

    1. Front Matter

      Pages 159-159

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      Book Chapter

      Pages 161-189

      Functional Impacts of Signal Integration: Regulation of Inflammation-Related Transcription Factors by Heterotrimeric G Proteins

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      Book Chapter

      Pages 191-242

      Molecular Cross-Talk Between Nuclear Receptors and Nuclear Factor-κB

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      Book Chapter

      Pages 243-262

      The Biomodulatory Capacities of Low-Dose Metronomic Chemotherapy: Complex Modulation of the Tumor Microenvironment

  5. Tumors are Evolvable Modular and Rationalized Systems: From Molecular to Modular Tumor Therapy

    1. Front Matter

      Pages 263-263

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      Book Chapter

      Pages 265-285

      Systems Biology: A Therapeutic Target for Tumor Therapy

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      Book Chapter

      Pages 287-303

      The Comparative Uncovering of Tumor Systems Biology by Modularly Targeting Tumor-Associated Inflammation

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      Book Chapter

      Pages 305-309

      Searching for the ‘Metabolism’ of Evolution

  6. Biomodulatory Therapy Approaches in Metastatic Cancer

    1. Front Matter

      Pages 311-311

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      Book Chapter

      Pages 313-340

      The Impact of Inflammation Control and Active Cancer Palliation on Metabolic Pathways Determining Tumor Progression and Patient Survival

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      Book Chapter

      Pages 341-352

      Pioglitazone and Rofecoxib Combined with Angiostatically Scheduled Capecitabine in Far-Advanced Hepatobiliary Carcinoma

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      Book Chapter

      Pages 353-366

      C-Reactive Protein As a Secretome-Derived Biomarker for Predicting Response to Biomodulatory Therapy in Metastatic Renal Clear Cell Carcinoma

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      Book Chapter

      Pages 367-377

      Modular Therapy Approach in Metastatic Castration-Resistent Prostate Cancer

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      Book Chapter

      Pages 379-382

      Systems-Directed Therapy in Metastatic Castration-Resistent Prostate Cancer (CRCP)

  7. Criteria for Checking Systems Behavior and Creating Predictions: Systems-Associated Biomarkers and Molecular Imaging

    1. Front Matter

      Pages 383-383

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      Book Chapter

      Pages 385-403

      Early Detection of Systems Response: Molecular and Functional Imaging of Angiogenesis

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