2011

Toxins and Hemostasis

From Bench to Bedside

ISBN: 978-90-481-9294-6 (Print) 978-90-481-9295-3 (Online)

Table of contents (43 chapters)

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  1. Front Matter

    Pages i-xxiii

  2. From bench to bedside

    1. Front Matter

      Pages 11-11

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      Book Chapter

      Pages 1-9

      Introduction

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      Book Chapter

      Pages 13-17

      From the Bothrops Jararaca Bradykinin Potentiating Peptides to Angiotensin Converting Enzyme Inhibitors

  3. The Omics – the search is on

    1. Front Matter

      Pages 19-19

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      Book Chapter

      Pages 21-44

      Sialomic Perspectives on the Evolution of Blood-Feeding Behavior in Arthropods: Future Therapeutics by Natural Design

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      Book Chapter

      Pages 45-72

      Snake Venomics, Antivenomics, and Venom Phenotyping: The Ménage à Trois of Proteomic Tools Aimed at Understanding the Biodiversity of Venoms

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      Book Chapter

      Pages 73-81

      Insights in to Venom and Toxin Activities and Pharmacological/Therapeutic Potential Using Gene Expression Profiling

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      Book Chapter

      Pages 83-95

      Bioactive Peptides and Proteins from Wasp Venoms

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      Book Chapter

      Pages 97-112

      The Theory of Intraspecies Variation is Not the Exception, But Simply the Rule: The Diverse Hemostatic Activities of Snake Venoms

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      Book Chapter

      Pages 113-130

      Tiny Ticks are Vast Sources of Antihaemostatic Factors

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      Book Chapter

      Pages 131-152

      Sialogenins and Immunomodulators Derived from Blood Feeding Parasites

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      Book Chapter

      Pages 153-164

      Salivary Protease Inhibitors with Non Anti-Hemostatic Functions

  4. Anticoagulant proteins

    1. Front Matter

      Pages 165-165

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      Book Chapter

      Pages 167-177

      Blood Coagulation Factor IX/Factor X-Binding Protein

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      Book Chapter

      Pages 179-199

      Bothrojaracin – A Potent Thrombin Inhibitor

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      Book Chapter

      Pages 201-217

      Anticoagulant Phospholipases A2 Which Bind to the Specific Soluble Receptor Coagulation Factor Xa

    5. Book Chapter

      Pages 219-237

      Hematophagy and Inhibition of the Extrinsic and Intrinsic Tenase Complexes

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      Book Chapter

      Pages 239-254

      Thrombin Inhibitors from Haematophagous Animals

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      Book Chapter

      Pages 255-266

      Anticoagulants from Scorpion Venoms

  5. Antiplatelet proteins

    1. Front Matter

      Pages 267-267

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      Book Chapter

      Pages 269-284

      The Discovery of Disintegrins

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      Book Chapter

      Pages 285-300

      Brief History and Molecular Determinants of Snake Venom Disintegrin Evolution

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      Book Chapter

      Pages 301-329

      Anti-Angiogenesis and Disintegrins

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      Book Chapter

      Pages 331-357

      Hematophagy and Inhibition of Platelet Aggregation

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