Volume 50 2010

Genome Stability and Human Diseases

Editors:

ISBN: 978-90-481-3470-0 (Print) 978-90-481-3471-7 (Online)

Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiii

  2. No Access

    Book Chapter

    Pages 1-15

    Coming Full Circle: Cyclin-Dependent Kinases as Anti-cancer Drug Targets

  3. No Access

    Book Chapter

    Pages 17-42

    Core and Linker Histone Modifications Involved in the DNA Damage Response

  4. No Access

    Book Chapter

    Pages 43-54

    Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56

  5. No Access

    Book Chapter

    Pages 55-78

    Structure and Function of Histone H2AX

  6. No Access

    Book Chapter

    Pages 79-104

    The Initiation Step of Eukaryotic DNA Replication

  7. No Access

    Book Chapter

    Pages 105-118

    Non-coding RNAs: New Players in the Field of Eukaryotic DNA Replication

  8. No Access

    Book Chapter

    Pages 119-141

    Function of TopBP1 in Genome Stability

  9. No Access

    Book Chapter

    Pages 143-163

    Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability

  10. No Access

    Book Chapter

    Pages 165-188

    DNA Polymerases and Mutagenesis in Human Cancers

  11. No Access

    Book Chapter

    Pages 189-209

    DNA Polymerase η, a Key Protein in Translesion Synthesis in Human Cells

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    Book Chapter

    Pages 211-222

    The Mitochondrial DNA Polymerase in Health and Disease

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    Book Chapter

    Pages 223-249

    Centromeres: Assembling and Propagating Epigenetic Function

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    Book Chapter

    Pages 251-277

    Nucleotide Excision Repair in Higher Eukaryotes: Mechanism of Primary Damage Recognition in Global Genome Repair

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    Book Chapter

    Pages 279-296

    Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans

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    Book Chapter

    Pages 297-306

    Fluorescence-Based Quantification of Pathway-Specific DNA Double-Strand Break Repair Activities: A Powerful Method for the Analysis of Genome Destabilizing Mechanisms

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    Book Chapter

    Pages 307-323

    Apoptosis: A Way to Maintain Healthy Individuals

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    Book Chapter

    Pages 325-336

    The Use of Transgenic Mice in Cancer and Genome Stability Research

  19. Back Matter

    Pages 337-340