Mechanosensitivity of the Heart

Editors:

ISBN: 978-90-481-2849-5 (Print) 978-90-481-2850-1 (Online)

Table of contents (17 chapters)

  1. Front Matter

    Pages i-xxxix

  2. Molecular Mechanisms of Mechanotransduction in Cardiac Cells

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-34

      Titin and Titin-Associated Proteins in Myocardial Stress-Sensing and Mechanical Dysfunction

    3. No Access

      Book Chapter

      Pages 35-54

      Mechanical Stretch-Induced Reorganization of the Cytoskeleton and the Small GTPase Rac-1 in Cardiac Fibroblasts

    4. No Access

      Book Chapter

      Pages 55-81

      Molecular Signaling Mechanisms of Myocardial Stretch: Implications for Heart Disease

    5. No Access

      Book Chapter

      Pages 83-95

      Mechanical Stress Induces Cardiomyocyte Hypertrophy Through Agonist-Independent Activation of Angiotensin II Type 1 Receptor

  3. Mechanically Induced Potentials and Currents of the Cardiac Cells in Healthy and Diseased Myocardium

    1. Front Matter

      Pages 97-97

    2. No Access

      Book Chapter

      Pages 99-139

      Mechanostransduction in Cardiac and Stem-Cell Derived Cardiac Cells

    3. No Access

      Book Chapter

      Pages 141-167

      Stretch-Activated Channels in the Heart: Contribution to Cardiac Performance

    4. No Access

      Book Chapter

      Pages 169-184

      Effects of Applied Stretch on Native and Recombinant Cardiac Na+ Currents

    5. No Access

      Book Chapter

      Pages 185-238

      Mechanosensitive Alterations of Action Potentials and Membrane Currents in Healthy and Diseased Cardiomyocytes: Cardiac Tissue and Isolated Cell

    6. No Access

      Book Chapter

      Pages 239-266

      The Role of Mechanosensitive Fibroblasts in the Heart: Evidence from Acutely Isolated Single Cells, Cultured Cells and from Intracellular Microelectrode Recordings on Multicellular Preparations from Healthy and Diseased Cardiac Tissue

    7. No Access

      Book Chapter

      Pages 267-272

      Scanning Ion Conductance Microscopy for Imaging and Mechanosensitive Activation of Selected Areas of Live Cells

  4. Mechano-Electric Feedback in the Whole Heart and a Computer Simulation Study

    1. Front Matter

      Pages 272-272

    2. No Access

      Book Chapter

      Pages 275-300

      The Contribution of MEF to Electrical Heterogeneity and Arrhythmogenesis

    3. No Access

      Book Chapter

      Pages 301-325

      Mechanical Modulation of a Reentrant Arrhythmia: The Atrial Flutter Case

    4. No Access

      Book Chapter

      Pages 327-371

      Early Hypertrophic Signals After Myocardial Stretch. Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger

    5. No Access

      Book Chapter

      Pages 373-385

      Stretch-Induced Inotropy in Atrial and Ventricular Myocardium

    6. No Access

      Book Chapter

      Pages 387-419

      Effects of Wall Stress on the Dynamics of Ventricular Fibrillation: A Computer Simulation Study of Mechanoelectric Feedback

    7. No Access

      Book Chapter

      Pages 421-449

      Electromechanical Modelling of Cardiac Tissue

  5. Arteries as a Source of Myogenic Contractile Activity: Ionic Mechanisms

    1. Front Matter

      Pages 451-451

    2. No Access

      Book Chapter

      Pages 453-481

      Specific Mechanotransduction Signaling Involved in Myogenic Responses of the Cerebral Arteries

  6. Back Matter

    Pages 483-485