New Challenges for Cancer Systems Biomedicine

Editors:

ISBN: 978-88-470-2570-7 (Print) 978-88-470-2571-4 (Online)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xi

  2. Towards a Comprehensive Theory of Cancer Growth

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-18

      Combining Game Theory and Graph Theory to Model Interactions between Cells in the Tumor Microenvironment

    3. No Access

      Book Chapter

      Pages 19-34

      Growth as the Root of all Evil in Carcinomas: Synergy between pH Buffering and Anti-Angiogenesis Prevents Emergence of Hallmarks of Cancer

    4. No Access

      Book Chapter

      Pages 35-51

      Phase Transitions in Cancer

  3. Cancer Related Signalling Pathways

    1. Front Matter

      Pages 53-53

    2. No Access

      Book Chapter

      Pages 55-82

      Spatio-Temporal Modelling of Intracellular Signalling Pathways: Transcription Factors, Negative Feedback Systems and Oscillations

    3. No Access

      Book Chapter

      Pages 83-104

      Understanding Cell Fate Decisions by Identifying Crucial System Dynamics

    4. No Access

      Book Chapter

      Pages 105-125

      Modelling Biochemical Pathways with the Calculus of Looping Sequences

    5. No Access

      Book Chapter

      Pages 127-142

      Dynamic Simulations of Pathways Downstream of TGFβ, Wnt and EGF-Family Growth Factors, in Colorectal Cancer, including Mutations and Treatments with Onco-Protein Inhibitors

  4. Basic Mechanisms of Tumor Progression

    1. Front Matter

      Pages 143-143

    2. No Access

      Book Chapter

      Pages 145-172

      Some Results on the Population Behavior of Cancer Stem Cells

    3. No Access

      Book Chapter

      Pages 173-190

      Glucose Metabolism in Multicellular Spheroids, ATP Production and Effects of Acidity

    4. No Access

      Book Chapter

      Pages 191-204

      Cell-Cell Interactions in Solid Tumors — the Role of Cancer Stem Cells

    5. No Access

      Book Chapter

      Pages 205-224

      Hybrid Cellular Potts Model for Solid Tumor Growth

  5. Tumor-Immune System Interplay and Immunotherapy

    1. Front Matter

      Pages 225-225

    2. No Access

      Book Chapter

      Pages 227-248

      Computational Models as Novel Tools for Cancer Vaccines

    3. No Access

      Book Chapter

      Pages 249-266

      On the Dynamics of Tumor-Immune System Interactions and Combined Chemo- and Immunotherapy

    4. No Access

      Book Chapter

      Pages 267-282

      Modeling the Kinetics of the Immune Response

  6. Computational Method for Improving Chemotherapy

    1. Front Matter

      Pages 283-283

    2. No Access

      Book Chapter

      Pages 285-299

      Optimizing Cancer Chemotherapy: From Mathematical Theories to Clinical Treatment

    3. No Access

      Book Chapter

      Pages 301-327

      A Systems Biomedicine Approach for Chronotherapeutics Optimization: Focus on the Anticancer Drug Irinotecan

    4. No Access

      Book Chapter

      Pages 329-336

      Modeling the Dynamics of HCV Infected Cells to Tailor Antiviral Therapy in Clinical Practice: Can This Approach Fit for Neoplastic Cells?

    5. No Access

      Book Chapter

      Pages 337-353

      Introducing Drug Transport Early in the Design of Hypoxia Selective Anticancer Agents Using a Mathematical Modelling Approach

    6. No Access

      Book Chapter

      Pages 355-375

      Top-Down Multiscale Simulation of Tumor Response to Treatment in the Context of In Silico Oncology. The Notion of Oncosimulator

    7. No Access

      Book Chapter

      Pages 376-398

      Challenges in the Integration of Flow Cytometry and Time-Lapse Live Cell Imaging Data Using a Cell Proliferation Model