Book 2009

The Biology of Krüppel-like Factors


ISBN: 978-4-431-87774-5 (Print) 978-4-431-87775-2 (Online)

Table of contents (18 chapters)

  1. Front Matter

    Pages i-viii

  2. Overview

    1. Chapter

      Pages 3-18

      Krüppel-like Factors: Ingenious Three Fingers Directing Biology and Pathobiology

  3. Molecular Control of Krüppel-like Factor Function

    1. Chapter

      Pages 21-31

      Molecular Structures of Krüppel-like Factors

    2. Chapter

      Pages 33-49

      Krüppel-like Factor Proteins and Chromatin Dynamics

    3. Chapter

      Pages 51-64

      Co-regulator Interactions in Krüppel-like Factor Transcriptional Programs

  4. Krüppel-like Factors in Development and Differentiation

    1. Chapter

      Pages 67-82

      Developmental Expression of Krüppel-like Factors

    2. Chapter

      Pages 83-93

      Expanded Role for EKLF/KLF1 Within the Hematopoietic Lineage

    3. Chapter

      Pages 95-106

      Roles of Krüppel-like Factors in Lymphocytes

    4. Chapter

      Pages 107-119

      Krüppel-like Factors in Gastrointestinal Tract Development and Differentiation

    5. Chapter

      Pages 121-130

      Gene Interactions Between Krüppel-like Factors in Development

    6. Chapter

      Pages 131-138

      Krüppel-like Factors in Stem Cell Biology

  5. Krüppel-like Factors in Organ Function and Disease

    1. Chapter

      Pages 141-150

      Krüppel-like Factors and the Liver

    2. Chapter

      Pages 151-157

      Role of Krüppel-like Factor 15 in Adipocytes

    3. Chapter

      Pages 159-171

      Krüppel-like Factors in the Heart

    4. Chapter

      Pages 173-184

      Krüppel-like Factors in the Vascular Endothelium

    5. Chapter

      Pages 185-204

      Krüppel-like Factors KLF2, KLF4, and KLF5: Central Regulators of Smooth Muscle Function

    6. Chapter

      Pages 205-219

      Krüppel-like Factors in Cancers

  6. Diagnostic and Therapeutic Applications of Krüppel-like Factors

    1. Chapter

      Pages 223-244

      Krüppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer

    2. Chapter

      Pages 245-252

      Drug Development and Krüppel-like Factors

  7. Back Matter

    Pages 253-258