Cell Therapy

  • Yasuo Ikeda
  • Jun-ichi Hata
  • Shigeo Koyasu
  • Yutaka Kawakami
  • Yutaka Hattori
Conference proceedings

DOI: 10.1007/978-4-431-68506-7

Part of the Keio University Symposia for Life Science and Medicine book series (KEIO, volume 5)

Table of contents (21 papers)

  1. Front Matter
    Pages I-XVI
  2. Immunotherapy for Malignant Diseases

    1. Front Matter
      Pages 1-1
    2. Breaking Immunological Tolerance to Tumor Cells as a Novel Immunotherapy for Cancer
      Shimon Sakaguchi, Takeshi Takahashi, Jun Shimizu
      Pages 3-13
    3. SART1 Gene Encoding Squamous Cell Carcinoma Antigen Recognized by Cytotoxic T Lymphocytes
      Kyogo Itoh, Shigeki Shichijo, Yoshiko Inoue, Akihiro Hayashi, Uhi Toh, Hideaki Yamana
      Pages 15-28
    4. Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clones
      Stanley R. Riddell, Edus H. Warren, Deborah Lewinsohn, Scott Brodie, Rici De Fries, Lawrence Corey et al.
      Pages 29-44
    5. Adoptive Transfer of Polyclonal, EBV-Specific Cytotoxic T-Cell Lines for the Prevention and Treatment of EBV-Associated Malignancies
      Cliona M. Rooney, M. Helen Huls, Richard A. Rochester, Malcolm K. Brenner, Helen E. Heslop
      Pages 45-60
  3. Hematopoietic Stem Cells Biology and Clinical Application

    1. Front Matter
      Pages 93-93
    2. Isolation and Characterization of CD34-Low/Negative Mouse Hematopoietic Stem Cells
      Hiromitsu Nakauchi, Masatake Osawa, Kazuhiro Sudo, Hideo Ema
      Pages 95-103
    3. Ex Vivo Expansion of Human Hematopoietic Stem Cells
      Tatsutoshi Nakahata, Ming-Jiang Xu, Takahiro Ueda, Sahoko Matsuoka, Mamoru Ito, Kohichiro Tsuji
      Pages 105-106
    4. Phase 1 Trial of Retroviral-Mediated Transfer of the Human MDR-1 in Patients Undergoing High-Dose Chemotherapy and Autologous Stem Cell Transplantation
      Charles Hesdorffer, Janet Ayello, Maureen Ward, Andreas Kaubisch, Arthur Bank, Karen Antman
      Pages 143-157
    5. Basic Studies Toward Hematopoietic Stem Cell Gene Therapy
      Yutaka Hanazono, Cynthia E. Dunbar, Robert E. Donahue, Ikunoshin Kato, Yasuji Ueda, Mamoru Hasegawa et al.
      Pages 159-169
    6. Ex Vivo Expansion of Hematopoietic Cells
      Ian McNiece, Roy Jones, Pablo Cagnoni, Scott Bearman, Yago Nieto, Elizabeth J. Shpall
      Pages 171-183
    7. Ex Vivo Expansion of Human Cord Blood Stem Cells and Genetic Manipulation
      Kiyoshi Ando, Hiroshi Kawada, Takashi Shimizu, Takashi Tsuji, Yoshihiko Nakamura, Minoru Kimura et al.
      Pages 195-204

About these proceedings


Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy.
All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy.
The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world.
The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy.


Carcinom Vivo bone bone marrow tranplantation cell biology cells gene therapy hematopoietic stem cell immunotherapy

Editors and affiliations

  • Yasuo Ikeda
    • 1
  • Jun-ichi Hata
    • 2
  • Shigeo Koyasu
    • 3
  • Yutaka Kawakami
    • 4
  • Yutaka Hattori
    • 1
  1. 1.Department of Internal MedicineKeio University School of MedicineShinjuku-ku, TokyoJapan
  2. 2.Department of PathologyKeio University School of MedicineShinjuku-ku, TokyoJapan
  3. 3.Department of MicrobiologyKeio University School of MedicineShinjuku-ku, TokyoJapan
  4. 4.Institute for Advanced Medical ResearchKeio University School of MedicineShinjuku-ku, TokyoJapan

Bibliographic information

  • Copyright Information Springer-Verlag Tokyo 2000
  • Publisher Name Springer, Tokyo
  • eBook Packages Springer Book Archive
  • Print ISBN 978-4-431-68508-1
  • Online ISBN 978-4-431-68506-7