Table of contents (27 papers)

  1. Front Matter
    Pages i-ix
  2. Basic Research for Innovative Medicine

    1. Front Matter
      Pages 1-1
    2. Diverting Glycolysis to Combat Oxidative Stress
      Edouard Mullarky, Lewis C. Cantley
      Pages 3-23 Open Access
    3. Metabolic Regulation by Nuclear Receptors
      Sihao Liu, Michael Downes, Ronald M. Evans
      Pages 25-37 Open Access
    4. Fighting Fire with Fire in Cancer
      Thorsten Berger, Mary E. Saunders, Tak W. Mak
      Pages 39-49 Open Access
    5. Roles of E-cadherin in Hepatocarcinogenesis
      Shin Maeda, Hayato Nakagawa
      Pages 71-77 Open Access
    6. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors
      Miki Nishio, Hiroki Goto, Miki Suzuki, Aya Fujimoto, Koshi Mimori, Akira Suzuki
      Pages 79-94 Open Access
    7. Inhibitory Immunoreceptors on Mast Cells in Allergy and Inflammation
      Akira Shibuya, Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka
      Pages 95-107 Open Access
    8. Doxycycline-Inducible Autoimmune Blistering Skin Disease Model
      Wataru Nishie, Hiroshi Shimizu
      Pages 109-117 Open Access
    9. T Cell Senescence and Autoimmunity
      Nagahiro Minato
      Pages 119-128 Open Access
  3. Translational Research for Innovative Medicine

    1. Front Matter
      Pages 129-129
    2. IL-6: A New Era for the Treatment of Autoimmune Inflammatory Diseases
      Tadamitsu Kishimoto, Sujin Kang, Toshio Tanaka
      Pages 131-147 Open Access
    3. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies
      Yoshihiro Ogawa, Takayoshi Suganami, Michiko Itoh, Miyako Tanaka
      Pages 149-156 Open Access
    4. Translational Research of Leptin in Lipodystrophy and Its Related Diseases
      Ken Ebihara, Kazuwa Nakao
      Pages 165-175 Open Access
    5. Clarity and Challenges in Tissue Fibrosis
      Scott L. Friedman
      Pages 187-194 Open Access
    6. TRP Channels: Their Function and Potentiality as Drug Targets
      Motohiro Nishida, Koichiro Kuwahara, Daisuke Kozai, Reiko Sakaguchi, Yasuo Mori
      Pages 195-218 Open Access

About these proceedings


This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.


Cancer Clinical application Metabolism Stem cell Translational research

Editors and affiliations

  • Kazuwa Nakao
    • 1
  • Nagahiro Minato
    • 2
  • Shinji Uemoto
    • 3
  1. 1.Medical Innovation CenterKyoto University Graduate School of MedicineKyotoJapan
  2. 2.Department of Immunology & Cell BiologyKyoto University Graduate School of MedicineKyotoJapan
  3. 3.Department of SurgeryKyoto University Graduate School of MedicineKyotoJapan

Bibliographic information

  • Copyright Information The Editor(s) (if applicable) and the Author(s) 2015
  • Publisher Name Springer, Tokyo
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-4-431-55650-3
  • Online ISBN 978-4-431-55651-0