PEGylated Protein Drugs: Basic Science and Clinical Applications

Editors:

ISBN: 978-3-7643-8678-8 (Print) 978-3-7643-8679-5 (Online)

Table of contents (16 chapters)

  1. Front Matter

    Pages I-IX

  2. No Access

    Book Chapter

    Pages 1-9

    Preface PEGylated protein conjugates: A new class of therapeutics for the 21st century

  3. No Access

    Book Chapter

    Pages 11-31

    Protein PEGylation, basic science and biological applications

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    Book Chapter

    Pages 33-45

    Reactive PEGs for protein conjugation

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    Book Chapter

    Pages 47-73

    Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation

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    Book Chapter

    Pages 75-88

    Enzymatic techniques for PEGylation of biopharmaceuticals

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    Book Chapter

    Pages 89-112

    The site-specific TGase-mediated PEGylation of proteins occurs at flexible sites

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    Book Chapter

    Pages 113-125

    Protein conjugates purification and characterization

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    Book Chapter

    Pages 127-146

    PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals

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    Book Chapter

    Pages 147-168

    The occurrence, induction, specificity and potential effect of antibodies against poly(ethylene glycol)

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    Book Chapter

    Pages 169-185

    Pegfilgrastim — designing an improved form of rmetHuG-CSF

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    Book Chapter

    Pages 187-203

    PEGylation of human growth hormone: strategies and properties

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    Book Chapter

    Pages 205-216

    PEGylated α interferons: two different strategies to achieve increased efficacy

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    Book Chapter

    Pages 217-227

    Development of PEGylated mammalian urate oxidase as a therapy for patients with refractory gout

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    Book Chapter

    Pages 229-254

    Certolizumab pegol: a PEGylated anti-tumour necrosis factor alpha biological agent

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    Book Chapter

    Pages 255-271

    PEG: a useful technology in anticancer therapy

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    Book Chapter

    Pages 273-281

    Regulatory strategy and approval processes considered for PEG-drug conjugates and other nanomedicines

  18. Back Matter

    Pages 283-287