Chemokine Biology — Basic Research and Clinical Application

Volume II: Pathophysiology of Chemokines


ISBN: 978-3-7643-7195-1 (Print) 978-3-7643-7437-2 (Online)

Table of contents (11 chapters)

  1. Front Matter

    Pages i-xii

  2. Chemokines in animal disease models

    1. Front Matter

      Pages 1-1

    2. Chapter

      Pages 3-17

      Chemokines in animal models of inflammation

    3. Chapter

      Pages 19-26

      Autoimmune diseases

    4. Chapter

      Pages 27-41

      Chemokines in allergic responses: eosinophils, basophils, mast cells

  3. Chemokines as drug targets

    1. Front Matter

      Pages 43-43

    2. Chapter

      Pages 45-59

      Chemokines as drug targets

    3. Chapter

      Pages 61-77

      Screening and characterization of cyclic pentapeptide CXCR4 antagonists/inverse agonists using a pheromone responsive reporter gene in Saccharomyces cerevisiae: Utility of G protein coupled receptor constitutively active mutants

    4. Chapter

      Pages 79-88

      Antagonists of CXCR3: a review of current progress

    5. Chapter

      Pages 89-102

      IL-8 receptor antagonist: basic research and clinical utility

    6. Chapter

      Pages 103-113

      Current status of CCR1 antagonists in clinical trials

    7. Chapter

      Pages 115-123

      Small molecule CCR2 antagonists

    8. Chapter

      Pages 125-144

      Chemokine axes in hematopoietic stem cell mobilization

    9. Chapter

      Pages 145-163

      CCR5 antagonists: from discovery to clinical efficacy

  4. Back Matter

    Pages 165-170