2013

Drug Resistance in Leishmania Parasites

Consequences, Molecular Mechanisms and Possible Treatments

Editors:

ISBN: 978-3-7091-0238-1 (Print) 978-3-7091-1125-3 (Online)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiv

  2. No Access

    Book Chapter

    Pages 1-12

    Introduction: Leishmaniasis – The Biology of a Parasite

  3. DETERMINANT FEATURES IN LEISHMANIASIS

    1. Front Matter

      Pages 13-13

    2. No Access

      Book Chapter

      Pages 15-44

      Molecular Evolution and Phylogeny of Leishmania

    3. No Access

      Book Chapter

      Pages 45-64

      The Role of Reservoirs: Canine Leishmaniasis

    4. No Access

      Book Chapter

      Pages 65-83

      Epidemiology of Leishmaniasis in the Time of Drug Resistance

  4. LEISHMANIA AND THE IMMUNE SYSTEM

    1. Front Matter

      Pages 85-85

    2. No Access

      Book Chapter

      Pages 87-112

      The Role of the Immune System in Resistance to Infection

    3. No Access

      Book Chapter

      Pages 113-141

      Vaccination as a Control Measure

    4. No Access

      Book Chapter

      Pages 143-163

      Leishmania Vaccines: Past, Present, and Future

  5. CHALLENGES IN THE DIAGNOSIS, TREATMENT AND CONTROL OF LEISHMANIASIS IN TIMES OF DRUG RESISTANCE

    1. Front Matter

      Pages 165-165

    2. No Access

      Book Chapter

      Pages 167-181

      Co-infection with HIV

    3. No Access

      Book Chapter

      Pages 183-198

      Visceral Leishmaniasis

    4. No Access

      Book Chapter

      Pages 199-211

      American Tegumentary Leishmaniasis

  6. MOLECULAR FEATURES OF DRUG-RESISTANT LEISHMANIA

    1. Front Matter

      Pages 213-213

    2. No Access

      Book Chapter

      Pages 215-236

      Genetic Expression and Drug Resistance, the Role of Proteomics

    3. No Access

      Book Chapter

      Pages 237-258

      The Role of ABC Transporters in Drug-Resistant Leishmania

    4. No Access

      Book Chapter

      Pages 259-284

      Functional Analysis of Leishmania Membrane (Non-ABC) Transporters Involved in Drug Resistance

    5. No Access

      Book Chapter

      Pages 285-297

      Intracellular Mechanisms of Resistance

  7. PHARMACOLOGY AND CHEMOTHERAPY OF LEISHMANIASIS

    1. Front Matter

      Pages 299-299

    2. No Access

      Book Chapter

      Pages 301-319

      Classical Versus Novel Treatment Regimens

    3. No Access

      Book Chapter

      Pages 321-350

      Drug Targets, Drug Effectors, and Drug Targeting and Delivery

    4. No Access

      Book Chapter

      Pages 351-379

      Mechanisms of Miltefosine Resistance in Leishmania

    5. No Access

      Book Chapter

      Pages 381-404

      P-glycoprotein-like Transporters in Leishmania: A Search for Reversal Agents

  8. STRATEGIES TO CIRCUMVENT DRUG RESISTANCE IN LEISHMANIA

    1. Front Matter

      Pages 405-405

    2. No Access

      Book Chapter

      Pages 407-429

      The Relevance of Susceptibility Tests, Breakpoints, and Markers

    3. No Access

      Book Chapter

      Pages 431-449

      The Concept of Fitness and Drug Resistance in Leishmania

  9. Back Matter

    Pages 451-459