Clinical Trials for the Treatment of Sepsis

ISBN: 978-3-642-79226-7 (Print) 978-3-642-79224-3 (Online)

Table of contents (25 chapters)

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  1. Front Matter

    Pages I-XXXI

  2. Epidemiology of Sepsis

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-12

      The Systemic Inflammatory Response Syndrome (SIRS)

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      Book Chapter

      Pages 13-34

      The “At Risk” Patient Population

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      Book Chapter

      Pages 35-51

      Outcome and Prognostic Factors in Bacteremic Sepsis

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      Book Chapter

      Pages 52-68

      ARDS and Sepsis: Resemblances and Differences

  3. Monitoring the Treatment of Sepsis

    1. Front Matter

      Pages 69-69

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      Book Chapter

      Pages 71-85

      Microbiological Requirements for Studies of Sepsis

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      Book Chapter

      Pages 86-105

      Measurement of Inflammatory Mediators in Clinical Sepsis

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      Book Chapter

      Pages 106-121

      Whole Body and Organ Measures of O2 Availability

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      Book Chapter

      Pages 122-138

      Multiple Organ Dysfunction Syndrome (MODS)

  4. Monitoring Illness Severity

    1. Front Matter

      Pages 139-139

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      Book Chapter

      Pages 141-156

      What Determines Prognosis in Sepsis?

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      Book Chapter

      Pages 157-164

      SAPS II and MPM II Models for Early Severe Sepsis

  5. Clinical Management of Sepsis

    1. Front Matter

      Pages 165-165

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      Book Chapter

      Pages 167-190

      Fluid Therapy in Septic Shock

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      Book Chapter

      Pages 191-206

      Role of RBC Transfusion Therapy in Sepsis

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      Book Chapter

      Pages 207-224

      Vasoactive Drug Therapy in Sepsis

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      Book Chapter

      Pages 225-233

      Evidence-Based Analysis of Nutrition Support in Sepsis

  6. Investigational Therapy of Sepsis

    1. Front Matter

      Pages 235-235

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      Book Chapter

      Pages 237-250

      Anti-Endotoxin Therapy

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      Book Chapter

      Pages 251-266

      Critical Reappraisal of Steroids and Other Anti-Inflammatory Agents

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      Book Chapter

      Pages 267-282

      Investigational Therapy of Sepsis: Anti-TNF, IL-1ra, Anti-PAF and G-CSF

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      Book Chapter

      Pages 283-298

      Sepsis and Acute Lung Injury

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      Book Chapter

      Pages 299-314

      Increasing Oxygen Delivery in Sepsis

  7. Designing the Optimum Clinical Trial for the Treatment of Sepsis

    1. Front Matter

      Pages 315-315

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      Book Chapter

      Pages 317-328

      Critical Evaluation of the Design and Conduct of Previous Clinical Trials in Sepsis

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