Arenaviruses

Genes, Proteins, and Expression

  • Michael B. A. Oldstone
Conference proceedings

DOI: 10.1007/978-3-642-71683-6

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 133)

Table of contents

  1. Front Matter
    Pages i-vii
  2. M. B. A. Oldstone
    Pages 1-4
  3. D. H. L. Bishop, D. D. Auperin
    Pages 5-17
  4. P. J. Southern, D. H. L. Bishop
    Pages 19-39
  5. M. J. Buchmeier, B. S. Parekh
    Pages 41-57
  6. S. J. Francis, P. J. Southern, A. Valsamakis, M. B. A. Oldstone
    Pages 67-88
  7. D. H. Walker, F. A. Murphy
    Pages 89-113
  8. Back Matter
    Pages 115-116

About these proceedings

Introduction

M. B. A. OLDSTONE Viruses are generally studied either because they cause significant human, animal or plant disease or for their utility as materials to probe a basic phenomenon in biology, chemistry, genetics or molecular biology. Arenaviruses are unusually interesting in that they occupy both of these categories. Arenaviruses cause severe human diseases known primarily as the hemor­ rhagic fevers occurring in South and Latin America (Bolivia: Machupo virus and Argentina: Junin virus) and in Africa (Lassa virus). Because such viruses produce profound disability and may kill the persons they infect, they are a source of economic hardship in the countries where they are prevalent. Further, they provide new problems for health care personnel owing to the narrowing of the world as visitors from many countries increasingly travel to and from these endemic areas. In addition, lymphocytic choriomeningitis virus (LCMV) can infect humans worldwide, although the illness is most often less disabling than those elicited by other arenaviruses. Yet LCMV is likely of greater concern to non-arena-virologists and experimentalists using tissue culture or animals, i. e. , workers in molecular biology, cancer research, virology, immunobiology, etc. , because normal appearing cultured cells or tissues and animals used for research may be persistently infected with LCMV without manifesting clinical disease or cytopathology and transmit that infection to laboratory workers (reviewed OWSTONE and PETERS 1978). For example, HINMAN et al.

Keywords

diseases genetics immunobiology infection molecular biology pathology protein proteins virology virus

Editors and affiliations

  • Michael B. A. Oldstone
    • 1
  1. 1.Department of ImmunologyScripps Clinic and Research FoundationLa JollaUSA

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71685-0
  • Online ISBN 978-3-642-71683-6
  • Series Print ISSN 0070-217X