Immunology of the Neonate

  • G. Roberto Burgio
  • Lars Åke Hanson
  • Alberto G. Ugazio
Conference proceedings

DOI: 10.1007/978-3-642-71094-0

Table of contents (19 papers)

  1. Front Matter
    Pages I-IX
  2. T-Cell Development
    O. Stutman
    Pages 5-26
  3. Humoral Immunity in the Human Neonate
    Joseph L. Butler, Takayo Suzuki, Hiromi Kubagawa, Max D. Cooper
    Pages 27-36
  4. The Ontogeny of the Immune Response: The Role of Maternal Factors
    L. Å. Hanson, I. Adlerberth, B. Carlsson, U. Dahlgren, Fehmida Jalil, Shaukat R. Khan et al.
    Pages 51-58
  5. Mononuclear Phagocyte Function in the Perinatal Period
    A. Biondi, G. Poli, C. Parravicini, A. Molinari, A. Mantovani
    Pages 59-66
  6. Complement Function in the Neonate
    F. Sessions Cole
    Pages 76-82
  7. T-Cell Development and Function: Relationship to Immunodeficiencies
    F. Aiuti, R. Paganelli, B. Ensoli, M. Crescenzi, M. Carbonari, M. Fiorilli
    Pages 94-99
  8. T and NK Lymphocyte Subpopulations in the Neonate
    Rita Maccario, G. R. Burgio
    Pages 120-129
  9. Immunity and Infections in the Neonate
    Joseph A. Bellanti, Barbara J. Zeligs
    Pages 135-144
  10. Intravenous Gammaglobulin Replacement for Prophylaxis of Infection in Preterm Neonates
    Gaetano Chirico, Giorgio Rondini, Alessandro Plebani, Alberto Chiara, Alberto G. Ugazio
    Pages 145-152
  11. Prevention of Atopy: Neonatal Aspects
    Robert N. Hamburger, Seth M. Asser
    Pages 153-160
  12. Summing Up
    Robert A. Good
    Pages 170-185

About these proceedings


Over the last few years, many new observations have profoundly changed our concepts of the immune competence of the newborn. For the immune system, as for other systems and functions, the neonatal age represents a crucial transition period. In fact the immune characteristics of the fetus are likely to result fro- or be conditioned by - several often contradictory physiological requirements. On the one hand, it would certainly be an advantage for the fetus to acquire a complete immunocompetence as soon as possible in order to be able to cope with the eventual transplacental passage of pathogenic microorganisms and possibly also in order to reject maternal cells occasionally crossing the placental nd barrier. This is actually what occurs, at least in part, during the 2 and Jfd month of gestation when the fetus begins to acquire his biological individuality and at the same time the role of a "biological ego" resulting from the attain­ ment by the immune system of the capacity to discriminate between self and nonself.


fetus immune system immunology newborn placenta

Editors and affiliations

  • G. Roberto Burgio
    • 1
  • Lars Åke Hanson
    • 2
  • Alberto G. Ugazio
    • 3
  1. 1.Clinica PediatricsUniversitá di PaviaPaviaItaly
  2. 2.Institute of Clinical MicrobiologyUniversity of GötebôrgGöteborgSweden
  3. 3.Clinica Pediatrica Ospedale dei BambiniUniversity of BresciaBresciaItaly

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 1987
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-71096-4
  • Online ISBN 978-3-642-71094-0