Lymphatic Metastasis and Sentinel Lymphonodectomy

  • Peter M. Schlag
  • Umberto Veronesi
Conference proceedings

DOI: 10.1007/978-3-642-57151-0

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 157)

Table of contents (26 papers)

  1. Front Matter
    Pages I-XII
  2. Clinical Assessment of Lymph Node Metastases

  3. Principles of Lymphatic Metastasis

    1. Front Matter
      Pages 39-39
    2. Molecular Diagnosis of Head and Neck Cancer
      V. M. M. van Houten, M. W. M. van den Brekel, F. Denkers, D. R. Colnot, J. Westerga, P. J. van Diest et al.
      Pages 90-106
  4. Principles of Lymphatic Mapping and Sentinel Node Detection

    1. Front Matter
      Pages 107-107
    2. The Concept of the Sentinel Lymph Node
      R. M. Cabanas
      Pages 109-120
    3. Vital Dye and Radiolabelled Colloids — Complement or Alternative
      R. Pijpers, P. J. Borgstein, G. J. J. Teule, S. Meijer
      Pages 130-137
  5. Sentinel Node Detection in Urogenital Cancer

  6. Sentinel Node Detection in Malignant Melanoma

    1. Front Matter
      Pages 159-159
    2. Sentinel Node Detection in Malignant Melanoma
      A. D. Chan, D. L. Morton
      Pages 161-177

About these proceedings

Introduction

Metastases determine malignancy. The main attention so far has been focused upon organ metastases. The molecular mechanisms thereof, while far from being totally elucidated, are increasingly well understood. Modern diagnostic tools now enable detection and precise localization of small lesions. In contrast, our knowl­ edge and diagnostic capabilities regarding metastatic spread to the'lymphatic system are rather limited. However, there have re­ cently been a number of interesting advances. It is the aim of this volume to submit these developments to detailed analysis. The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in­ creased morbidity versus eventual prognostic improvements by modification of therapy. An interesting concept which might im­ prove diagnostic accuracy while reducing operative morbidity is the "sentinel node" technique. Surgical standards are lacking, however, and many fundamental questions pertaining to precise lymphatic mapping remain unanswered. Whether the sentinel node concept is of general relevance or whether it is applicable in only a few organs remains to be determined. This book offers intensive discussion of the concept from methodological and tu­ mor biological viewpoints. World-renowned experts with long­ term involvement in related basic and clinical research provide the reader with a broad survey of actual knowledge together with a critical appraisal of recent and future developments. We sincerely hope this book succeeds in providing an outlook as a reference for all clinicians on future prospects and serving and researchers in this extremely important field.

Keywords

Lymph node metastasis Staging Tumor biopsy carcinoma cell biology diagnosis fluorescence lymphating mapping lymphonodectomy positron emission tomography sentinel lymph node surgery tumor staging ultrasound

Editors and affiliations

  • Peter M. Schlag
    • 1
  • Umberto Veronesi
    • 2
  1. 1.Klinik für Chirurgie und chirurgische Onkologie Robert-Rössle-KlinikUniversitätsklinikum CharitéBerlinGermany
  2. 2.Istituto Europeo di OncologiaMilanoItaly

Bibliographic information

  • Copyright Information Springer-Verlag Berlin · Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-63070-5
  • Online ISBN 978-3-642-57151-0
  • Series Print ISSN 0080-0015