Vitamin D Analogs in Cancer Prevention and Therapy

ISBN: 978-3-642-62435-3 (Print) 978-3-642-55580-0 (Online)

Table of contents (31 chapters)

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  1. Front Matter

    Pages I-VIII

  2. Molecular Biology of Vitamin D

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-28

      Evolution and Function of Vitamin D

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      Book Chapter

      Pages 29-42

      Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural and Synthetic Ligands

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      Book Chapter

      Pages 43-54

      Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk

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      Book Chapter

      Pages 55-82

      Ligand Structure—Function Relationships in the Vitamin D Endocrine System from the Perspective of Drug Development (Including Cancer Treatment)

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      Book Chapter

      Pages 83-98

      Antiproliferative Signalling by 1, 25(OH)2D3in Prostate and Breast Cancer Is Suppressed by a Mechanism Involving Histone Deacetylation

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      Book Chapter

      Pages 99-110

      Mechanisms Implicated in the Growth Regulatory Effects of Vitamin D Compounds in Breast Cancer Cells

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      Book Chapter

      Pages 111-122

      Squamous Cell Carcinomas Fail to Respond to the Prodifferentiating Actions of 1,25(OH)2D3: Why?

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      Book Chapter

      Pages 123-134

      A Novel Vitamin D-Regulated Immediate-Early Gene, IEX-1, Alters Cellular Growth and Apoptosis

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      Book Chapter

      Pages 135-145

      Extrarenal Sites of Calcitriol Synthesis:The Particular Role of the Skin

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      Book Chapter

      Pages 147-149

      Cultured Rat Growth Plate Chondrocytes Express Low Levels of 1α-Hydroxylase

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      Book Chapter

      Pages 151-155

      Gene Amplification and Splice Variants of 25-Hydroxyvitamin D31, α-Hydroxylase (CYP27B1) in Glioblastoma Multiforme— A Possible Role in Tumor Progression?

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      Book Chapter

      Pages 157-167

      Regulation of the 25-Hydroxyvitamin D-1α-Hydroxylase Gene and Its Splice Variant

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      Book Chapter

      Pages 169-188

      Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolism

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      Book Chapter

      Pages 189-202

      Importance Of Cytochrome P450-Mediated Metabolism in the Mechanism of Action of Vitamin D Analogs

  3. The Vitamin D System in Cancer

    1. Front Matter

      Pages 203-203

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      Book Chapter

      Pages 205-221

      The Role of Vitamin D in Prostate Cancer

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      Book Chapter

      Pages 223-237

      Vitamin D Autocrine System and Prostate Cancer

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      Book Chapter

      Pages 239-246

      Analysis of the Vitamin D System in Cervical Carcinomas, Breast Cancer and Ovarian Cancer

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      Book Chapter

      Pages 247-257

      Short-Chain Fatty Acids and Colon Cancer Cells: The Vitamin D Receptor—Butyrate Connection

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      Book Chapter

      Pages 259-269

      Analysis of the Vitamin D system in Cutaneous Malignancies

  4. Antitumor Effects of Vitamin D Analogs

    1. Front Matter

      Pages 271-271

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      Book Chapter

      Pages 273-288

      Evaluation of Vitamin D Analogs as Therapeutic Agents for Prostate Cancer

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